Evidence map›Paper›PMID 32691280›Full record

ArticleJournal of molecular neuroscience : MN2021

RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats.

Xiaoxing Tan, Yuchong Wei, Jie Cao, Degang Wu, Niansheng Lai, Ruming Deng, Haiying Li, Haitao Shen, Ya Peng, Xiang Li and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiaoxing TanDepartment of Neurosurgery, The Third Affiliated Hospital of Soochow University, Juqian Street, Changzhou, 213003, Jiangsu Province, China.
Yuchong WeiDepartment of Neurosurgery, The Third Affiliated Hospital of Soochow University, Juqian Street, Changzhou, 213003, Jiangsu Province, China.
Jie CaoDepartment of Neurosurgery, The Third Affiliated Hospital of Soochow University, Juqian Street, Changzhou, 213003, Jiangsu Province, China.
Degang WuDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Niansheng LaiDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Ruming DengDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Haiying LiDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Haitao ShenDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Ya PengDepartment of Neurosurgery, The Third Affiliated Hospital of Soochow University, Juqian Street, Changzhou, 213003, Jiangsu Province, China. neuropengya@sina.com.
Xiang LiDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China. 714306945@qq.com.ORCID http://orcid.org/0000-0002-1639-6017
Gang ChenDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Soochow University · CN

Funding

Jiangsu Provincial Medical Youth Talent QNRC2016728National Key R&D Program of China 2018YFC1312600 and 2018YFC1312601Natural Science Foundation of Jiangsu Province BK20170363Natural Science Foundation of Jiangsu Province BK20180204Project of Jiangsu Provincial Medical Innovation Team CXTDA2017003Scientific Department of Jiangsu Province BE2017656Suzhou Government LCZX201601Suzhou Key Medical Centre Szzx201501
6 · The paper itself

Abstract

RAB7, a member of RAS oncogene family-like 1 (RAB7L1), is a GTPase belonging to the Rab family and acts as an upstream regulator to regulate the kinase activity of leucine-rich repeat kinase 2 (LRRK2). Although LRRK2 has been shown to aggravate secondary brain injury (SBI) after intracerebral hemorrhage (ICH), it is unknown whether RAB7L1 is also involved in this process. The purpose of the present study was to investigate the role of RAB7L1 in ICH-induced SBI in vivo. Autologous blood was injected into adult male Sprague-Dawley rats to induce an ICH model in vivo. The results showed that the protein levels of RAB7L1 increased after ICH. Overexpression of RAB7L1 induced neuronal apoptosis and damage, as demonstrated by TUNEL-positive and FJB-positive cells, and exacerbated ICH-induced learning and cognitive dysfunctions; in contrast, downregulation of RAB7L1 via RNA interference yielded comparatively opposite changes in these parameters. In summary, this study demonstrates that RAB7L1 promotes SBI after ICH and may represent a potential target for ICH therapy.

Indexed as

AnimalsApoptosisBasal GangliaBloodBrain Damage, ChronicCerebral HemorrhageCognition DisordersDisease Models, AnimalGene Expression RegulationInjectionsInjections, IntraventricularLearning DisabilitiesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MaleMorris Water Maze TestNerve Tissue ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, ratNerve Tissue ProteinsRab29 protein, ratrab GTP-Binding ProteinsRNA, Small InterferingApoptosisIntracerebral hemorrhageRab7L1Secondary brain injury

Identifiers

PMID32691280
OpenAlexW3045489293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.