ArticleJournal of the Association for Research in Otolaryngology : JARO2020
Relationships between Intrascalar Tissue, Neuron Survival, and Cochlear Implant Function.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Electrode impedance in cochlear implantation: determinants, dynamics, and clinical implications.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Integrating Computational Modelling into the Ecosystem of Cochlear Implantation: Advancing Access to Diagnostics, Decision-Making, and Post-Implantation Outcomes on a Global Scale.Journal of clinical medicine · 2025Article
- Visualization of the Spiral Ganglion Neuron in Vivo Using a NovelAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival.Journal of functional biomaterials · 2025Article
- Concentration Dependent Effects of Human Cometin on Spiral Ganglion Neuron Survival and Neurite Outgrowth.Audiology & neuro-otology · 2025Article
- Electrical Bioimpedance-Based Monitoring of Intracochlear Tissue Changes After Cochlear Implantation.Sensors (Basel, Switzerland) · 2024Article
- Differentiation of Spiral Ganglion Neurons from Human Dental Pulp Stem Cells: A Further Step towards Autologous Auditory Nerve Recovery.International journal of molecular sciences · 2024Article
- Insights Into Electrophysiological Metrics of Cochlear Health in Cochlear Implant Users Using a Computational Model.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Early Loss of Spiral Ganglion Neurons in the Auditory System after Noise Trauma.Audiology & neuro-otology · 2024Article
- Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation.Laryngoscope investigative otolaryngology · 2023Article
- Using x-ray micro computed tomography to quantify intracochlear fibrosis after cochlear implantation in a Guinea pig model.Heliyon · 2023Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Electrical Field Interactions during Adjacent Electrode Stimulations: eABR Evaluation in Cochlear Implant Users.Journal of clinical medicine · 2023Article
- Changes in the Electrically Evoked Compound Action Potential over time After Implantation and Subsequent Deafening in Guinea Pigs.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- The intraoperative relationship between intracochlear electrical field and excitability of the auditory nerve.Heliyon · 2022Article
- Components of impedance in a cochlear implant animal model with TGFβ1-accelerated fibrosis.Hearing research · 2022Article
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Estimating health of the implanted cochlea using psychophysical strength-duration functions and electrode configuration.Hearing research · 2022Article
- Using the electrically-evoked compound action potential (ECAP) interphase gap effect to select electrode stimulation sites in cochlear implant users.Hearing research · 2021Article
- Development of a chronically-implanted mouse model for studies of cochlear health and implant function.Hearing research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Fibrous tissue and/or new bone are often found surrounding a cochlear implant in the cochlear scalae. This new intrascalar tissue could potentially limit cochlear implant function by increasing impedance and altering signaling pathways between the implant and the auditory nerve. In this study, we investigated the relationship between intrascalar tissue and 5 measures of implant function in guinea pigs. Variation in both spiral ganglion neuron (SGN) survival and intrascalar tissue was produced by implanting hearing ears, ears deafened with neomycin, and neomycin-deafened ears treated with a neurotrophin. We found significant effects of SGN density on 4 functional measures but adding intrascalar tissue level to the analysis did not explain more variation in any measure than was explained by SGN density alone. These results suggest that effects of intrascalar tissue on electrical hearing are relatively unimportant in comparison to degeneration of the auditory nerve, although additional studies in human implant recipients are still needed to assess the effects of this tissue on complex hearing tasks like speech perception. The results also suggest that efforts to minimize the trauma that aggravates both tissue development and SGN loss could be beneficial.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.