Evidence map›Paper›PMID 32691236›Full record

SynthesisJournal of neurology2021

A systematic review of neurological symptoms and complications of COVID-19.

Xiangliang Chen, Sarah Laurent, Oezguer A Onur, Nina N Kleineberg, Gereon R Fink, Finja Schweitzer, Clemens Warnke

2 registry-linked trialsOpen access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 152 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 10 pooled it
22.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05067881 completednot on this map

Post COVID-19 Pneumo-hematocele: Clinical Presentation and Treatment Pathway

TypeobservationalSponsorHospital General Ajusco MedioRan2020 to 2021Enrolled37ConditionsCOVID-19 Respiratory InfectionArmsPulmonary resection
NCT05171946 phase1unknown statusnot on this mapstarted 2022, after this paper: background citation

Phase-I, Single Center, Randomized, Dosage Finding Study, to Evaluate the Safety, Tolerability, and Immunogenicity of a Prophylactic COVID-19 pDNA Vaccine After Multiple Ascending Doses in Healthy Adults

TypeinterventionalSponsorIman AlmansourRan2022 to 2023Enrolled30ConditionsSafety, Vaccine Reaction, Vaccine Adverse Reaction, ImmunizationArmsS.opt.FL COVID-19 pDNA vaccine
3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 10 syntheses or guidelines pooled it, 293 citations in OpenAlex.

  1. Pooled it
  2. [Report of 3 cases of acute hemorrhagic leukoencephalitis in Mexico].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Pooled it
  3. Pooled it
  4. Hearing loss and COVID-19: an umbrella review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. COVID-19 in People Living with HIV: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  11. Article
  12. Article
  13. Analytical review of facial nerve palsy following SARS-CoV-2 vaccination: comprehensive assessment.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Review
  14. New mouse model for inducible hACE2 expression enables to dissect SARS-CoV-2 pathology beyond the respiratory system.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Xiangliang Chen *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Sarah Laurent *Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.
Oezguer A OnurDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.
Nina N KleinebergDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.
Gereon R FinkDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.
Finja Schweitzer *Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany. finja.schweitzer@uk-koeln.de.
Clemens Warnke *Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany. clemens.warnke@uk-koeln.de.ORCID http://orcid.org/0000-0002-3510-9255
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the frequency of neurological symptoms and complications in COVID-19 patients in a systematic review of the literature.

methodsRelevant studies were identified through electronic explorations of PubMed, medRxiv, and bioRxiv. Besides, three Chinese databases were searched. A snowballing method searching the bibliographies of the retrieved references was applied to identify potentially relevant articles. Articles published within 1 year prior to April 20th, 2020, were screened with no language restriction imposed. Databases were searched for terms related to SARS-CoV-2/COVID-19 and neurological manifestations, using a pre-established protocol registered on the International Prospective Register of Systematic Reviews database (ID: CRD42020187994).

resultsA total of 2441 articles were screened for relevant content, of which 92 full-text publications were included in the analyses of neurological manifestations of COVID-19. Headache, dizziness, taste and smell dysfunctions, and impaired consciousness were the most frequently described neurological symptoms, the latter more often among patients with a severe or critical disease course. To date, only smaller cohort studies or single cases have reported cerebrovascular events, seizures, meningoencephalitis, and immune-mediated neurological diseases, not suitable for quantitative analysis.

conclusionThe most frequent neurological symptoms reported in association with COVID-19 are non-specific for the infection with SARS-CoV-2. Although SARS-CoV-2 may have the potential to gain direct access to the nervous system, so far, SARS-CoV-2 was detected in the cerebrospinal fluid in two cases only. Standardized international registries are needed to clarify the clinical relevance of the neuropathogenicity of SARS-CoV-2 and to elucidate a possible impact of SARS-CoV-2 infection on common neurological disease, such as Alzheimer's, Parkinson's disease or multiple sclerosis.

Indexed as

COVID-19HumansNervous System DiseasesCOVID-19Nervous systemNeuro-COVIDSARS-CoV-2

Identifiers

PMID32691236
PMCPMC7370630
OpenAlexW3043216367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.