Evidence map›Paper›PMID 32691215›Full record

SynthesisWiener klinische Wochenschrift2020

Impella in cardiogenic shock following acute myocardial infarction: a systematic review and meta-analysis.

Kris G Vargas, Bernhard Jäger, Christoph C Kaufmann, Andrea Biagioli, Stephan Watremez, Fernando Gatto, Cem Özbek, Amjad Razouk, Alexander Geppert, Kurt Huber

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Wiener klinische Wochenschrift, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Neurocritical Care of Mechanical Circulatory Support Devices.Current neurology and neuroscience reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Kris G Vargas3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen Hospital, Vienna, Austria. krisgregoryvargas@gmail.com.
Bernhard Jäger3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen Hospital, Vienna, Austria.
Christoph C Kaufmann3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen Hospital, Vienna, Austria.
Andrea BiagioliDepartment of Cardiology and Angiology, HerzZentrum Saar, Völklingen, Germany.
Stephan WatremezDepartment of Cardiology and Angiology, HerzZentrum Saar, Völklingen, Germany.
Fernando GattoDepartment of Cardiology and Angiology, HerzZentrum Saar, Völklingen, Germany.
Cem ÖzbekDepartment of Cardiology and Angiology, HerzZentrum Saar, Völklingen, Germany.
Amjad RazoukDepartment of Cardiology, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.
Alexander Geppert3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen Hospital, Vienna, Austria.
Kurt Huber3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen Hospital, Vienna, Austria.
Wilhelminen Hospital · ATUniversitätsklinikum des Saarlandes · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveCardiogenic shock (CS) conveys a high mortality risk. A cardiac assist device may serve as bridge to patient recovery. We aimed to provide a pooled estimate on mortality and complications from studies evaluating the use of the left ventricular assist device Impella in CS following acute myocardial infarction. In addition, we evaluated whether mortality risk differed with device placement before or after percutaneous coronary intervention (PCI).

methodsWe searched Medline, Embase and Web of Science from 2005 until July 2019 for observational studies or clinical trials on this specific patient group. Studies were required to report on 30-day all-cause mortality and device-related complications. We calculated pooled proportions with 95% confidence intervals (CI) using random effects models and the inverse variance method.

resultsOverall, 671 patients from 11 studies (2 randomized and 9 observational) were included. Pooled proportions showed a 30-day mortality of 54.6% (95% CI 47.3-61.8; P = 0.22; I

conclusionPooled estimates of Impella use in myocardial infarction with CS revealed a high 30-day mortality; however, as compared to post-PCI, Impella initiation prior to PCI was associated with a survival benefit.

Indexed as

Heart-Assist DevicesMyocardial InfarctionPercutaneous Coronary InterventionHemorrhageHumansShock, CardiogenicTreatment OutcomeCardiogenic shockHeart-assist devicesImpellaMechanical circulatory supportMyocardial infarction

Identifiers

PMID32691215
OpenAlexW3044227178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.