ArticleJournal of mathematical biology2020
Modelling dendritic spines with the finite element method, investigating the impact of geometry on electric and calcic responses.
Article in Journal of mathematical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- How do signals propagate in neuronal compartments? Insights from the Poisson-Nernst Planck model.Frontiers in cellular neuroscience · 2026Article
- Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines.Biophysical journal · 2025Review
- Ion-concentration gradients induced by synaptic input increase the voltage depolarization in dendritic spines.Journal of computational neuroscience · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Understanding the relationship between shape and function of dendritic spines is an elusive topic. Several modelling approaches have been used to investigate the interplay between spine geometry, calcium diffusion and electric signalling. We here use a second order finite element method to solve the Poisson-Nernst-Planck equations and describe electrodiffusion in dendritic spines. With this, we obtain relationships between dendritic geometry and calcic as well as electric responses to synaptic events. Our findings support the hypothesis that spine geometry plays a role shaping the electrical responses to synaptic events. Our method was also able to reveal the fine scale distribution of calcium in spines with irregular shapes.
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