Evidence map›Paper›PMID 32691015›Full record

ArticleInfectious Disease Modelling2020

Using statistics and mathematical modelling to understand infectious disease outbreaks: COVID-19 as an example.

Christopher E Overton, Helena B Stage, Shazaad Ahmad, Jacob Curran-Sebastian, Paul Dark, Rajenki Das, Elizabeth Fearon, Timothy Felton, Martyn Fyles, Nick Gent and 9 more

Abstract read
In one paragraph

Article in Infectious Disease Modelling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Variant-Specific Viral Kinetics in Acute COVID-19.The Journal of infectious diseases · 2023
    Trial
  2. Article
  3. Article
  4. Forecasting the Monkeypox Outbreak Using Limited Data: A Case Study of Thailand.Interdisciplinary perspectives on infectious diseases · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Nowcasting the 2022 mpox outbreak in England.PLoS computational biology · 2023
    Article
  13. Article
  14. Article
  15. Evaluating COVID-19 risk under the estimation of population mean using two attributes.Concurrency and computation : practice & experience · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christopher E OvertonDepartment of Mathematics, University of Manchester, UK.
Helena B StageDepartment of Mathematics, University of Manchester, UK.
Shazaad AhmadDepartment of Virology, Manchester Medical Microbiology Partnership, Manchester Foundation Trust, UK.
Jacob Curran-SebastianDepartment of Mathematics, University of Manchester, UK.
Paul DarkDivision of Infection, Immunity and Respiratory Medicine, NIHR Biomedical Research Centre, University of Manchester, UK.
Rajenki DasDepartment of Mathematics, University of Manchester, UK.
Elizabeth FearonDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, UK.
Timothy FeltonDivision of Infection, Immunity and Respiratory Medicine, NIHR Biomedical Research Centre, University of Manchester, UK.
Martyn FylesDepartment of Mathematics, University of Manchester, UK.
Nick GentEmergency Response Department, Public Health England, UK.
Ian HallDepartment of Mathematics, University of Manchester, UK.
Thomas HouseDepartment of Mathematics, University of Manchester, UK.
Hugo LewkowiczDepartment of Health Sciences, University of Manchester, UK.
Xiaoxi PangDepartment of Mathematics, University of Manchester, UK.
Lorenzo PellisDepartment of Mathematics, University of Manchester, UK.
Robert SawkoIBM Research, Hartree Centre, SciTech Daresbury, UK.
Andrew UstianowskiRegional Infectious Diseases Unit, North Manchester General Hospital, UK.
Bindu VekariaDepartment of Mathematics, University of Manchester, UK.
Luke WebbDepartment of Mathematics, University of Manchester, UK.

Funding

Medical Research Council MR/S020462/1Medical Research Council MR/V038613/1Wellcome Trust
6 · The paper itself

Abstract

During an infectious disease outbreak, biases in the data and complexities of the underlying dynamics pose significant challenges in mathematically modelling the outbreak and designing policy. Motivated by the ongoing response to COVID-19, we provide a toolkit of statistical and mathematical models beyond the simple SIR-type differential equation models for analysing the early stages of an outbreak and assessing interventions. In particular, we focus on parameter estimation in the presence of known biases in the data, and the effect of non-pharmaceutical interventions in enclosed subpopulations, such as households and care homes. We illustrate these methods by applying them to the COVID-19 pandemic.

Indexed as

BiasCOVID-19Epidemic modellingInterventionOutbreakParameter estimation

Identifiers

PMID32691015
PMCPMC7334973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.