ArticleNature microbiology2020
Doubling of the known set of RNA viruses by metagenomic analysis of an aquatic virome.
Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
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Who cites it
147 citing papers in PubMed.
- The origins and evolution of the RNA virome in land flora.Molecular plant · 2026Article
- Diversity of Antarctic sea ice and under-ice seawater RNA viruses.Applied and environmental microbiology · 2026Article
- RdRpCATCH: a unified resource for RNA virus discovery using viral RNA-dependent RNA polymerase profile Hidden Markov models.NAR genomics and bioinformatics · 2026Article
- RNAViruses · 2026Review
- Diversity and distinctive characteristics of the global RNA virome in urban and peri-urban environments.Nature communications · 2026Article
- Predicting the evolutionary and functional landscapes of viruses with a unified nucleotide-protein language model: LucaVirus.National science review · 2026Article
- Metagenomic Characterization and Molecular Screening of Pathogens in Freshwater Amphipods (Pathogens (Basel, Switzerland) · 2026Article
- A comprehensive RNA virome from molluscan transcriptomes reveals extensive diversity and modular genome evolution.Virologica Sinica · 2026Article
- Metatranscriptomic discovery of a novel viral class from the Yangshan deep-water port virosphere.Archives of virology · 2026Article
- Near-complete genome sequences of marna- and nora-like picornaviruses from small pond water in Japan.Microbiology resource announcements · 2026Article
- Identification of hot spring Obelisk-like RNA replicons and expanded diversity of the Obelisk superfamily.Nature communications · 2026Article
- Longitudinal sampling of New Zealand cockles (Austrovenus stutchburyi) reveals high viral diversity and taxa-specific responses to environmental factors.FEMS microbiology ecology · 2026Article
- Article
- Molecular architecture and diversity of StopGo/2A translational recoding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- VIRE: a metagenome-derived, planetary-scale virome resource with environmental context.Nucleic acids research · 2026Article
- Identification and characterization of a novel plaque-invisible lytic single-stranded RNA phage.Journal of virology · 2025Article
- The dynamics of single stranded, positive sense RNA bacteriophages in the rumen virome.Scientific reports · 2025Article
- Identification of Obelisk-like covalently closed circular RNA replicon in hot springs by double-stranded RNA sequencing and expansion of the diversity of the Obelisk superfamily.bioRxiv : the preprint server for biology · 2025Article
- Quantifying viral load and characterizing virus diversity in wildlife samples with target enrichment sequencing.Microbial genomics · 2025Article
- Virus taxonomy proposal summaries: a searchable and citable resource to disseminate virus taxonomy advances.The Journal of general virology · 2025Article
87 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
RNA viruses in aquatic environments remain poorly studied. Here, we analysed the RNA virome from approximately 10 l water from Yangshan Deep-Water Harbour near the Yangtze River estuary in China and identified more than 4,500 distinct RNA viruses, doubling the previously known set of viruses. Phylogenomic analysis identified several major lineages, roughly, at the taxonomic ranks of class, order and family. The 719-member-strong Yangshan virus assemblage is the sister clade to the expansive class Alsuviricetes and consists of viruses with simple genomes that typically encode only RNA-dependent RNA polymerase (RdRP), capping enzyme and capsid protein. Several clades within the Yangshan assemblage independently evolved domain permutation in the RdRP. Another previously unknown clade shares ancestry with Potyviridae, the largest known plant virus family. The 'Aquatic picorna-like viruses/Marnaviridae' clade was greatly expanded, with more than 800 added viruses. Several RdRP-linked protein domains not previously detected in any RNA viruses were identified, such as the small ubiquitin-like modifier (SUMO) domain, phospholipase A2 and PrsW-family protease domain. Multiple viruses utilize alternative genetic codes implying protist (especially ciliate) hosts. The results reveal a vast RNA virome that includes many previously unknown groups. However, phylogenetic analysis of the RdRPs supports the previously established five-branch structure of the RNA virus evolutionary tree, with no additional phyla.
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