Evidence map›Paper›PMID 32690910›Full record

ReviewNature reviews. Cardiology2020

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives.

Masataka Nishiga, Dao Wen Wang, Yaling Han, David B Lewis, Joseph C Wu

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 758 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
758citing papers in PubMed, 7 pooled it
31.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05279378 completednot on this mapstarted 2022, after this paper: background citation

Correlation of Lung Ultrasonography With Chest CT Findings in Cancer Patients With COVID-19 Viral Pneumonia, an Observational Study

Typeobservational_patient_registrySponsorSouth Egypt Cancer InstituteRan2022 to 2025Enrolled30ConditionsCancer PatientsArmslung ultrasonography versus CT
NCT05379556 recruitingnot on this mapstarted 2022, after this paper: background citation

LOng COvid COmorbidities: Evaluation of Andrological, Reproductive and Sexual Functions in Patients Recovered From COVID-19

TypeobservationalSponsorFederico II UniversityRan2022 to 2027Enrolled100ConditionsLong Covid-19ArmsAssessment of andrological profile of LO-COCO-ANDRO male patients, Assessment of reproductive function of LO-COCO-ANDRO male patients, Assessment of sexual function of LO-COCO-ANDRO male patients, Assessment of olfactory function of LO-COCO-ANDRO male and female patients
3 · Its place in the literature

Who cites it

758 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,455 citations in OpenAlex.

  1. Pooled it
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  6. COVID-19-associated Brugada pattern electrocardiogram: Systematic review of case reports.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Pooled it
  7. Pooled it
  8. Trial
  9. Article
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  13. Review
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  15. Regional inequities in myocardial infarction burden in Brazil's public healthcare system.Archives of public health = Archives belges de sante publique · 2026
    Article
  16. Article
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  18. "Bridging the clinical, molecular and genetic perspectives on myocarditis in post-COVID-19 era".International journal of cardiology. Cardiovascular risk and prevention · 2026
    Review
  19. Review
  20. Article

698 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Masataka NishigaStanford Cardiovascular Institute, Stanford, CA, USA. mnishiga@stanford.edu.ORCID http://orcid.org/0000-0001-5676-7671
Dao Wen WangDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Yaling HanCardiovascular Research Institute, Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.
David B LewisDivision of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Joseph C WuStanford Cardiovascular Institute, Stanford, CA, USA. joewu@stanford.edu.ORCID http://orcid.org/0000-0002-6068-8041
Cardiovascular Institute of the South · USStanford University · USTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic that has affected the lives of billions of individuals. Extensive studies have revealed that SARS-CoV-2 shares many biological features with SARS-CoV, the zoonotic virus that caused the 2002 outbreak of severe acute respiratory syndrome, including the system of cell entry, which is triggered by binding of the viral spike protein to angiotensin-converting enzyme 2. Clinical studies have also reported an association between COVID-19 and cardiovascular disease. Pre-existing cardiovascular disease seems to be linked with worse outcomes and increased risk of death in patients with COVID-19, whereas COVID-19 itself can also induce myocardial injury, arrhythmia, acute coronary syndrome and venous thromboembolism. Potential drug-disease interactions affecting patients with COVID-19 and comorbid cardiovascular diseases are also becoming a serious concern. In this Review, we summarize the current understanding of COVID-19 from basic mechanisms to clinical perspectives, focusing on the interaction between COVID-19 and the cardiovascular system. By combining our knowledge of the biological features of the virus with clinical findings, we can improve our understanding of the potential mechanisms underlying COVID-19, paving the way towards the development of preventative and therapeutic solutions.

Indexed as

Cardiovascular DiseasesCoronavirus InfectionsPandemicsPneumonia, ViralBetacoronavirusComorbidityCOVID-19Disease ManagementHumansRisk FactorsSARS-CoV-2

Identifiers

PMID32690910
PMCPMC7370876
OpenAlexW3043773740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.