Evidence map›Paper›PMID 32690871›Full record

ArticleMucosal immunology2021

A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice.

Xiaoyun Wang, Joselyn Rojas-Quintero, Duo Zhang, Takahiro Nakajima, Katherine H Walker, Hong Yong Peh, Yuhong Li, Quynh-Anh Fucci, Yohannes Tesfaigzi, Caroline A Owen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Xiaoyun WangDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Joselyn Rojas-QuinteroDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Duo ZhangProgram in Clinical and Experimental Therapeutics, Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA, 30901, USA.
Takahiro NakajimaDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Katherine H WalkerDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Hong Yong PehDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Yuhong LiDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Quynh-Anh FucciDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Yohannes TesfaigziDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Caroline A OwenDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. cowenusa@yahoo.com.ORCID http://orcid.org/0000-0003-4377-3591
Brigham and Women's Hospital · USUniversity of Georgia · US

Funding

Resolution of Epithelial Cell Hyperplasia in AsthmaR01HL068111 · NHLBI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI TESFAIGZI, YOHANNES · 2003 to 2021
$10.9M
Targeting MMP9 to Improve Outcomes in Serious Influenza InfectionsR01AI111475 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HARROD, KEVIN S, LEVY, BRUCE D · 2014 to 2018
$4.3M
Wood Smoke and Chronic Mucous HypersecretionR01HL140839 · NHLBI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI TESFAIGZI, YOHANNES · 2018 to 2021
$2.8M
Novel Roles for MMP-8 in Acute Lung InjuryR01HL063137 · NHLBI · UNIVERSITY OF UTAH · PI OWEN, CAROLINE A · 1999 to 2008
$2.6M
Novel Roles for ADAM15 in Acute Lung InjuryR01HL086814 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OWEN, CAROLINE A · 2007 to 2010
$1.6M
Novel Anti-inflammatory Activities For ADAM8 In Pulmonary EmphysemaR21HL111835 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OWEN, CAROLINE A · 2012 to 2013
$456k
MMP-8 Deficiency Improves Host Responses to Influenza Viral InfectionsF32HL147437 · NHLBI · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2019 to 2021
$205k
NHLBI NIH HHS F32 HL147437NHLBI NIH HHS R01 HL063137NHLBI NIH HHS R01 HL068111NHLBI NIH HHS R01 HL086814NHLBI NIH HHS R01 HL140839NHLBI NIH HHS R21 HL111835NIAID NIH HHS R01 AI111475
6 · The paper itself

Abstract

A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by cells implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), but its contributions to COPD are unknown. To address this gap, ADAM15 levels were measured in samples from cigarette smoke (CS)-versus air-exposed wild-type (WT) mice. CS-induced COPD-like disease was compared in CS-exposed WT, Adam15

Indexed as

ADAM ProteinsAnimalsCD8-Positive T-LymphocytesCells, CulturedCigarette SmokingDisease Models, AnimalHumansLungLymphocyte DepletionMacrophages, AlveolarMembrane ProteinsMiceMice, KnockoutMitochondriaPneumoniaPulmonary Disease, Chronic ObstructiveAdam15 protein, mouseADAM ProteinsMembrane ProteinsTOR Serine-Threonine Kinases

Identifiers

PMID32690871
PMCPMC8422911
OpenAlexW3042291172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.