ArticleMolecular psychiatry2021
Optogenetic manipulation of an ascending arousal system tunes cortical broadband gamma power and reveals functional deficits relevant to schizophrenia.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Baclofen-associated neurophysiologic target engagement across species in fragile X syndrome.Journal of neurodevelopmental disorders · 2022Trial
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- Loss of connexin 36 elicits abnormalities in thalamocortical network activity relevant to neuropsychiatric disorders.Translational psychiatry · 2026Article
- Ventral pallidum efferent pathways via mediodorsal thalamus and lateral habenula mediate default mode network regulation.iScience · 2025Article
- The Application of Gamma-Range Auditory Steady-State Responses in Animal Models: A Semi-Structured Literature Review.Brain sciences · 2025Review
- Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology.Molecular psychiatry · 2025Review
- Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Basal forebrain parvalbumin neurons modulate vigilant attention and rescue deficits produced by sleep deprivation.Journal of sleep research · 2024Article
- Article
- Gamma Oscillations and Potassium Channel Modulation in Schizophrenia: Targeting GABAergic Dysfunction.Clinical EEG and neuroscience · 2024Article
- Review
- Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia.Current topics in behavioral neurosciences · 2023Review
- The contribution of gamma bursting to spontaneous gamma activity in schizophrenia.Frontiers in human neuroscience · 2023Article
- Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Role of the locus coeruleus and basal forebrain in arousal and attention.Brain research bulletin · 2022Review
- Subcortical control of the default mode network: Role of the basal forebrain and implications for neuropsychiatric disorders.Brain research bulletin · 2022Review
- Translational approaches to influence sleep and arousal.Brain research bulletin · 2022Review
- Review
- Optogenetics: implications for Alzheimer's disease research and therapy.Molecular brain · 2022Review
Corrections and comments
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Authors and funding
11 authors.
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Abstract
Increases in broadband cortical electroencephalogram (EEG) power in the gamma band (30-80 Hz) range have been observed in schizophrenia patients and in mouse models of schizophrenia. They are also seen in humans and animals treated with the psychotomimetic agent ketamine. However, the mechanisms which can result in increased broadband gamma power and the pathophysiological implications for cognition and behavior are poorly understood. Here we report that tonic optogenetic manipulation of an ascending arousal system bidirectionally tunes cortical broadband gamma power, allowing on-demand tests of the effect on cortical processing and behavior. Constant, low wattage optogenetic stimulation of basal forebrain (BF) neurons containing the calcium-binding protein parvalbumin (PV) increased broadband gamma frequency power, increased locomotor activity, and impaired novel object recognition. Concomitantly, task-associated gamma band oscillations induced by trains of auditory stimuli, or exposure to novel objects, were impaired, reminiscent of findings in schizophrenia patients. Conversely, tonic optogenetic inhibition of BF-PV neurons partially rescued the elevated broadband gamma power elicited by subanesthetic doses of ketamine. These results support the idea that increased cortical broadband gamma activity leads to impairments in cognition and behavior, and identify BF-PV activity as a modulator of this activity. As such, BF-PV neurons may represent a novel target for pharmacotherapy in disorders such as schizophrenia which involve aberrant increases in cortical broadband gamma activity.
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