Evidence map›Paper›PMID 32690705›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Co-option of the lineage-specific

Mariam Okhovat, Kimberly A Nevonen, Brett A Davis, Pryce Michener, Samantha Ward, Mark Milhaven, Lana Harshman, Ajuni Sohota, Jason D Fernandes, Sofie R Salama and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Mariam OkhovatDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239; okhovat@ohsu.edu carbone@ohsu.edu.ORCID 0000-0002-3145-9397
Kimberly A NevonenDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239.
Brett A DavisDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239.
Pryce MichenerDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239.
Samantha WardDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239.
Mark MilhavenDepartment of Ecology and Evolution, Institute for Advance Computational Science, Stony Brook University, Stony Brook, NY 11794.
Lana HarshmanDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.
Ajuni SohotaDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.
Jason D FernandesDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-8625-1796
Sofie R SalamaDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA 95064.ORCID 0000-0001-6999-7193
Rachel J O'NeillInstitute for Systems Genomics, University of Connecticut, Storrs, CT 06269.
Nadav AhituvDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.ORCID 0000-0002-7434-8144
Krishna R VeeramahDepartment of Ecology and Evolution, Institute for Advance Computational Science, Stony Brook University, Stony Brook, NY 11794.
Lucia CarboneDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239; okhovat@ohsu.edu carbone@ohsu.edu.ORCID 0000-0002-2118-107X
Oregon Health & Science University · USUniversity of California, San Francisco · USStony Brook University · USHoward Hughes Medical Institute · USOregon National Primate Research Center · USUniversity of California, Santa Cruz · USUniversity of Connecticut · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Comparative and functional analysis of conservation and rearrangement of topologically associating domains across mammals.R01HG010333 · NHGRI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CARBONE, LUCIA · 2018 to 2021
$2.8M
Evolution of new regulatory networks via genetic arms races between KRAB zinc finger proteins and retrotransposonsR01HG010329 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SALAMA, SOFIE REDA · 2019 to 2022
$2.7M
Evolutionary and Mechanistic Investigations of Transposable Element Exaptation by KRAB-Zinc Finger ProteinsF32GM125388 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI FERNANDES, JASON · 2018 to 2018
$63k
NHGRI NIH HHS R01 HG010329NHGRI NIH HHS R01 HG010333NIGMS NIH HHS F32 GM125388NIH HHS P51 OD011092
6 · The paper itself

Abstract

Co-option of transposable elements (TEs) to become part of existing or new enhancers is an important mechanism for evolution of gene regulation. However, contributions of lineage-specific TE insertions to recent regulatory adaptations remain poorly understood. Gibbons present a suitable model to study these contributions as they have evolved a lineage-specific TE called

Indexed as

GenomeRetroelementsAnimalsChromatinEvolution, MolecularGene Expression RegulationHylobatesMutagenesis, InsertionalRegulatory Sequences, Nucleic AcidSpecies SpecificityChromatinRetroelementscis-regulatory elementco-optionDNA repairtranscription factor bindingtransposable element

Identifiers

PMID32690705
PMCPMC7431028
OpenAlexW3042284795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.