Evidence map›Paper›PMID 32690627›Full record

ArticleMolecular pharmacology2020

Differing Activity Profiles of the Stereoisomers of 2,3,5,6TMP-TQS, a Putative Silent Allosteric Modulator of

Roger L Papke, Sumanta Garai, Clare Stokes, Nicole A Horenstein, Arthur D Zimmerman, Khalil A Abboud, Ganesh A Thakur

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Differential Activation and Desensitization States Promoted by NoncanonicalThe Journal of pharmacology and experimental therapeutics · 2022
    Article
  3. Review
  4. Stable desensitization of αEuropean journal of pharmacology · 2021
    Article
  5. Article
  6. Therapeutic Targeting ofPharmacological reviews · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Roger L PapkeDepartments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.) rlpapke@ufl.edu g.thakur@northeastern.edu.
Sumanta GaraiDepartments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Clare StokesDepartments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Nicole A HorensteinDepartments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Arthur D ZimmermanDepartments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Khalil A AbboudDepartments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Ganesh A ThakurDepartments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.) rlpapke@ufl.edu g.thakur@northeastern.edu.
Northeastern University · USUniversity of Florida · US

Funding

Targeting of Alpha7 nAChR for therapeutic effectsR01GM057481 · NIGMS · UNIVERSITY OF FLORIDA · PI PAPKE, ROGER L · 2000 to 2023
$7.6M
A Novel Pharmacotherapy for GlaucomaR01EY024717 · NEI · NORTHEASTERN UNIVERSITY · PI THAKUR, GANESH A · 2014 to 2018
$2.2M
NEI NIH HHS R01 EY024717NIGMS NIH HHS R01 GM057481
6 · The paper itself

Abstract

Many synthetic compounds to which we attribute specific activities are produced as racemic mixtures of stereoisomers, and it may be that all the desired activity comes from a single enantiomer. We have previously shown this to be the case with the

Indexed as

Allosteric Regulationalpha7 Nicotinic Acetylcholine ReceptorAnimalsAnimals, Genetically ModifiedBinding SitesHumansModels, MolecularMolecular Docking SimulationMolecular StructureMutationStereoisomerismSulfonamidesXenopus laevisalpha7 Nicotinic Acetylcholine ReceptorChrna7 protein, humanSulfonamides

Identifiers

PMID32690627
PMCPMC7472127
OpenAlexW3044461943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.