ArticleBMJ open diabetes research & care2020
Survival and factors predicting mortality after major and minor lower-extremity amputations among patients with diabetes: a population-based study using health information systems.
Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of PostAmputation Pain With Targeted Muscle Reinnervation: A National, Multicenter, Randomized, Sham-controlled Superiority Trial, Comparing Standard Neurectomy With Targeted Muscle Reinnervation in Amputations of the Lower Extremities
Evaluation of a New Diagnostic Tool (MinION) for Identifying Microorganisms in the Foot Wounds of Patients Living With Diabetic Foot Osteomyelitis (DFOM)
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global Epidemiology of Diabetic Foot: A Systematic Review and Meta-Analysis.Diabetes/metabolism research and reviews · 2026Pooled it
- Phantom Limb Pain and Painful Neuroma After Dysvascular Lower-Extremity Amputation: A Systematic Review and Meta-Analysis.Vascular and endovascular surgery · 2024Pooled it
- Incidence and Risk Factors of Stump Complications Following Amputation in Patients With Diabetes: A Retrospective Analysis of the Nationwide Inpatient Sample.World journal of surgery · 2026Article
- Article
- Post-below-knee amputation venous thromboembolism and mortality in United States veterans.Research and practice in thrombosis and haemostasis · 2025Article
- Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications.Clinical epidemiology · 2025Article
- Mortality Rates of Minor vs Major Lower Extremity Amputations in Diabetic Patients.Acta medica Lituanica · 2025Article
- Personalized and predictive strategies for diabetic foot ulcer prevention and therapeutic management: potential improvements through introducing Artificial Intelligence and wearable technology.Medicine and pharmacy reports · 2024Review
- Temporal trends in lower extremity amputation in Middle East and North Africa (MENA) region: analysis of the GBD dataset 1990-2019.International journal for equity in health · 2024Article
- Factors Affecting 30-Day Outcomes in Patients Undergoing Nontraumatic Upper Extremity Amputation: A Retrospective Descriptive Longitudinal Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
- Risk of Heart Disease in Patients With Amputation: A Nationwide Cohort Study in South Korea.Journal of the American Heart Association · 2024Article
- Independent association of history of diabetic foot with all-cause mortality in patients with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study.Cardiovascular diabetology · 2024Observational
- Age Characteristics of Patients With Type 2 Diabetic Foot Ulcers and Predictive Risk Factors for Lower Limb Amputation: A Population-Based Retrospective Study.Journal of diabetes research · 2024Article
- Association of remoteness and ethnicity with major amputation following minor amputation to treat diabetes-related foot disease.PloS one · 2024Article
- Micronutrient status in patients with diabetic foot ulcers: A cross-sectional study in Saudi Arabia.Journal of family medicine and primary care · 2024Article
- Lipid Profile Paradox: Investigating Improved Lipid Levels in Diabetic Mellitus Patients with Foot Ulcer Infections-A Prospective Descriptive Study.Diagnostics (Basel, Switzerland) · 2023Article
- Life Expectancy and Mortality After Lower Extremity Amputation: Overview and Analysis of Literature.Cureus · 2023Review
- Comparison of Operational Definition of Type 2 Diabetes Mellitus Based on Data from Korean National Health Insurance Service and Korea National Health and Nutrition Examination Survey.Diabetes & metabolism journal · 2023Article
- Phenotypic and Genotypic Virulence Characterisation ofInternational journal of molecular sciences · 2022Article
- Analysis of the factors affecting mortality after non-traumatic major lower extremity amputations.Acta orthopaedica et traumatologica turcica · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of the study was to identify the sociodemographic and clinical factors associated with death after the first lower-extremity amputation (LEA), minor and major separately, using data from regional health administrative databases. RESEARCH DESIGN AND
methodsWe carried out a population-based cohort study including patients with diabetes residing in the Lazio region and undergoing a primary amputation in the period 2012-2015. Each individual was followed up for at least 2 years. Kaplan-Meier analysis was used to evaluate long-term survival; Cox proportional regression models were applied to identify factors associated with all-cause mortality.
resultsThe cohort included 1053 patients, 72% were male, 63% aged ≥65 years, and 519 (49%) died by the end of follow-up. Mortality rates at 1 and 4 years were, respectively, 33% and 65% for major LEA and 18% and 45% for minor LEA. Significant risk factors for mortality were age ≥65, diabetes-related cardiovascular complications, and chronic renal disease for patients with minor LEA, and age ≥75 years, chronic renal disease and antidepressant drug consumption for subjects with major LEA.
conclusionsThe present study confirms the high mortality rates described in patients with diabetes after non-traumatic LEA. It shows differences between minor and major LEA in terms of mortality rates and related risk factors. The study highlights the role of depression as specific risk factor for death in patients with diabetes after major LEA and suggests including its definition and management in strategies to reduce the high mortality rate observed in this group of patients.
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Registered trials
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