Evidence map›Paper›PMID 32690553›Full record

ArticleOpen heart2020

Heart team approach in treatment of mitral regurgitation: patient selection and outcome.

Mischa Külling, Roberto Corti, Georg Noll, Silke Küest, David Hürlimann, Christophe Wyss, Ivano Reho, Felix C Tanner, Jeremy Külling, Nicolai Meinshausen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Open heart, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. The current state of the multidisciplinary heart team approach: a systematic review.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
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  18. Transcatheter mitral valve intervention.The British journal of cardiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Mischa KüllingFaculty of Medicine, University of Zurich, Zurich, Switzerland.
Roberto CortiHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Georg NollHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Silke KüestHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
David HürlimannHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Christophe WyssHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Ivano RehoHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Felix C TannerDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Jeremy KüllingSwiss Federal Institute of Technology, Zurich, Switzerland.
Nicolai MeinshausenSwiss Federal Institute of Technology, Zurich, Switzerland.
Oliver GaemperliHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Peter WenaweserHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Sacha P SalzbergHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Thierry AymardHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Jürg GrünenfelderHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland.
Patric BiaggiHeart Clinic Zurich, Hirslanden Hospital Hirslanden, Zurich, Switzerland patric.biaggi@hirslanden.ch.ORCID 0000-0003-3445-7060
Klinik Hirslanden · CHÉcole Polytechnique Fédérale de Lausanne · CHUniversity Hospital of Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA multidisciplinary heart valve team is recommended for the evaluation of treatment in patients with valvular heart disease, but evidence supporting this concept is lacking. In patients with severe mitral regurgitation, we thought to analyse the patient selection process by the heart team for different treatment options and the outcome after treatment.

methodsIn this single-centre cohort study, all patients treated for mitral regurgitation between July 2013 and September 2018 were included. Primary end points during follow-up were all-cause mortality and a combined end point, consisting of all-cause mortality, cardiovascular rehospitalisation and mitral valve reintervention.

results179 patients (44.8%) were treated using Mitraclip, 185 (46.2%) by surgical repair and 36 (9.0%) by surgical replacement. The mortality risk according to EuroScore II differed significantly between treatment groups (6.6%±5.6%, 1.7%±1.5% and 3.6%±2.7% for Mitraclip, surgical repair and replacement, respectively, p<0.001). In-hospital mortality for the 3 groups were 3.4%, 1.6% and 8.3%, respectively (p=0.091). Overall, surgical repair patients had higher 4-year survival (HR 0.40 (95% CI 0.26 to 0.63), p<0.001) and fewer combined end points (HR 0.51 (95% CI 0.32 to 0.80), p<0.001) compared with surgical replacement and Mitraclip patients. However, patients undergoing Mitraclip for isolated, primary mitral regurgitation achieved very good long-term survival.

conclusionThe multidisciplinary heart team assigned only low-risk patients with favourable anatomy to surgical repair, while high-risk patients underwent Mitraclip or surgical replacement. This strategy was associated with lower than expected in-hospital mortality for Mitraclip patients and high 4-year survival rates for patients undergoing surgical or percutaneous repair of isolated primary mitral regurgitation.

Indexed as

Heart Valve Prosthesis ImplantationMitral Valve AnnuloplastyPatient Care TeamAgedAged, 80 and overClinical Decision-MakingFemaleHeart Valve ProsthesisHemodynamicsHospital MortalityHumansMaleMiddle AgedMitral ValveMitral Valve InsufficiencyPatient Readmissionmitral regurgitationpercutaneous valve therapysurgery-valve

Identifiers

PMID32690553
PMCPMC7371220
OpenAlexW3043204471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.