Evidence map›Paper›PMID 32690135›Full record

ArticleeLife2020

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging

Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley I Bush, Gawain McColl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

  1. Ferroptosis and Senescence: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  2. Review
  3. Ferroptosis as a target mechanism in heart and kidney disease.The Journal of clinical investigation · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Syringaresinol Attenuates Aging-Associated Ferroptosis-Relevant Stress Through an HIF-1α-GPX4 Defense Axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Nicole L JenkinsMelbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, Australia.
Simon A JamesAustralian Synchrotron, ANSTO, Clayton, Australia.
Agus SalimDepartment of Mathematics and Statistics, La Trobe University, Bundoora, Australia.
Fransisca SumardyMelbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, Australia.
Terence P SpeedBioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Marcus ConradHelmholtz Zentrum München, Institute of Metabolism and Cell Death, Neuherberg, Germany.
Des R RichardsonDepartment of Pathology and Bosch Institute, University of Sydney, Sydney, Australia.
Ashley I BushMelbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, Australia.
Gawain McCollMelbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, Australia.ORCID 0000-0002-6347-6722
The University of Melbourne · AUAustralian Nuclear Science and Technology Organisation · AUHelmholtz Zentrum München · DEThe University of Sydney · AU

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Morphine Induced Modulation of Tumor GrowthF31DA021005 · NIDA · UNIVERSITY OF MINNESOTA · PI KOODIE, LISA · 2006 to 2008
$92k
NIDA NIH HHS F31 DA021005NIH HHS P40 OD010440
6 · The paper itself

Abstract

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed

Indexed as

AgingAnimalsCaenorhabditis elegansFerroptosisFrailtyGlutathioneIronGlutathioneIronbiochemistryC. eleganschemical biologyferroptosisfitnessfrailtyglutathioneironlifespan

Identifiers

PMID32690135
PMCPMC7373428
OpenAlexW3045152875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.