Observational studyInternational breastfeeding journal2020
Interactions between cortisol and lipids in human milk.
Observational study in International breastfeeding journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Maternal separation-induced changes in breast milk fatty acid composition are associated with altered gut microbiota and serotonergic gene expression in neonatal mice.Molecular biomedicine · 2026Article
- Impact of breast milk composition on nutritional status of term neonates with congenital heart defects: A prospective study.World journal of clinical pediatrics · 2026Article
- Postpartum Maternal Stress is Unrelated to the Infant Fecal Microbiome, but is Associated With the Human Milk Microbiome in Exclusively Breastfeeding Mother-Infant Dyads: The Mother-Infant Microbiomes, Behavior, and Ecology Study (MIMBES).American journal of human biology : the official journal of the Human Biology Council · 2025Article
- The association between maternal stress and human milk concentrations of cortisol and prolactin.Scientific reports · 2024Article
- Regulation of Milk Fat Synthesis: Key Genes and Microbial Functions.Microorganisms · 2024Review
- Composition and Antioxidant Status of Human Milk of Women Living in Bydgoszcz (Poland).Nutrients · 2024Article
- The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period.Animals : an open access journal from MDPI · 2023Review
- The contributions of parental lactation on offspring development: It's not udder nonsense!Hormones and behavior · 2023Review
- Lactation in the human.Animal frontiers : the review magazine of animal agriculture · 2023Article
- Analysis of serum metabolism in premature infants before and after feeding using GC-MS and the relationship with necrotizing enterocolitis.Biomedical chromatography : BMC · 2023Article
- Maternal stress is associated with higher protein-bound amino acid concentrations in human milk.Frontiers in nutrition · 2023Article
- Factors Influencing Cortisol Concentrations in Breastmilk and Its Associations with Breastmilk Composition and Infant Development in the First Six Months of Lactation.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman breast milk is one of the key early postnatal biological exposures for the developing child. It includes bioactive compounds, such as cortisol and fatty acids, which may be linked via the mother's lipid metabolism.
methodsThis study investigated the associations between cortisol and lipids in human milk at the infant age of 2.5 months. Human milk cortisol concentrations were measured using luminescence immunoassay, and two groups of milks (n = 50 each) were formed based on either high (> 10 nmol/L) or low (< 3 nmol/L) cortisol levels. Lipids, as fatty acid content and composition of neutral (triacylglycerol-rich) and polar (phospholipid-rich) lipids, were measured with gas chromatography. The samples originated from the FinnBrain Birth Cohort Study.
resultsThe percentage of phospholipid-rich lipids of total lipids was 33.08% ± 1.33%. In triacylglycerol-rich lipids, high cortisol level in milk was associated with higher lauric (12:0, mass % and mg/mL), myristic (14:0, mass % and mg/mL), eicosenoic (20:1n - 9, mass %), docosenoic (22:1n - 9, mass %, and mg/mL) acids, and to lower palmitic acid (16:0, mass %) compared with low cortisol levels in milk. In phospholipid-rich lipids, high cortisol level was associated with higher myristic (14:0, mass %) and docosenoic (22:1n - 9, mass %) acids. After adjusting for pre-pregnancy BMI and sampling time by linear regression, the milk cortisol remained a significant predictor for lauric and myristic acids in triacylglycerol-rich lipids, and myristic and docosenoic acid in phospholipid-rich lipids (β = 0.23 to 0.38 and p < 0.05 for each).
conclusionsThis study revealed certain significant associations between milk cortisol and the fatty acid composition of human milk, indicating that cortisol might be one of the factors affecting the origin of the lipids in human milk.
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