ArticleJournal of hematology & oncology2020
Epidemiological trends of tracheal, bronchus, and lung cancer at the global, regional, and national levels: a population-based study.
Article in Journal of hematology & oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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119 citing papers in PubMed, 284 citations in OpenAlex.
- The shifting burden of tracheal, bronchus and lung cancer in ageing Asia: structural drivers and projections to 2050.Annals of medicine · 2026Article
- Global burden and trends of tracheal, bronchus, and lung cancer in adolescents and young adults: a secondary analysis of the Global Burden of Disease Study 2021.Journal of thoracic disease · 2026Article
- Diverging Trajectories of Lung Cancer Burden in China, Japan, and South Korea: A Comparative Risk Assessment from the Global Burden of Disease Study 1990-2021.Thoracic cancer · 2026Article
- Global, regional and national burden of chronic obstructive pulmonary disease and lower respiratory infection attributable to household air pollution and secondhand smoke from 1990 to 2021: an analysis of the Global Burden of Disease Study (GBD 2021).Journal of thoracic disease · 2026Article
- Chronic hepatitis B virus infection and the risk of extrahepatic malignancies: an updated review of epidemiology, mechanisms, and clinical implications.Virology journal · 2026Review
- Global burden of lung cancer attributable to secondhand smoke (1990-2021) and predictive trends to 2035.Medicine · 2026Article
- Knowledge and Awareness of the General Public on Lung Cancer Screening Modalities and Lung Cancer Preventive Methods in Riyadh, Saudi Arabia.Current oncology (Toronto, Ont.) · 2026Article
- Age-sex differences in the global burden of asthma and risk factors, 1990-2021: results from the global burden of disease study 2021.BMC pulmonary medicine · 2026Article
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- Global, regional, and national burden and trends of liver cancer due to hepatitis B in young adults from 1990 to 2021 and forecast to 2030: insights from the Global Burden of Disease Study 2021.Internal and emergency medicine · 2026Article
- Impact of smoking cessation on survival and treatment tolerability in advanced non-small cell lung cancer: a single-center experience from Morocco.Ecancermedicalscience · 2026Article
- Global, Regional, and National Burden of Adolescent Polycystic Ovary Syndrome from 1990 to 2021, with Projections of Disease Burden to 2041: A Systematic Analysis Based on the Global Burden of Disease Study 2021.International journal of women's health · 2026Article
- Design and Engineering of Recombinant Oncolytic Adenoviruses Expressing an Anti-EpCAM/Anti-CD3 BiTE for Targeted Immunotherapy of A549 Lung Cancer Cells.OncoTargets and therapy · 2026Article
- Operative lung cancer patients' knowledge of pulmonary rehabilitation.Frontiers in physiology · 2026Article
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- Global Patterns and Trends in Lifetime Risks of Developing and Dying from Cancer, 1990-2021.Health data science · 2026Article
- Decomposition analysis of lung cancer and COPD mortality attributable to ambient PMAsia-Pacific journal of oncology nursing · 2025Article
- Epidemiological trends of osteoarthritis at the global, regional, and national levels from 1990 to 2021 and projections to 2050.Arthritis research & therapy · 2025Article
- Global, regional, and national trends and inequality analysis of the total cancers and 29 cancer types from 1990 to 2021.BMC public health · 2025Article
- Trends in cancer burden for adolescents and young adults in China from 1990 to 2021.BMC cancer · 2025Article
59 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInvestigations of disease incidence, mortality, and disability-adjusted life years (DALYs) are valuable for facilitating preventive measures and health resource planning. We examined the tracheal, bronchus, and lung (TBL) cancer burdens worldwide according to sex, age, and social development index (SDI) at the global, regional, and national levels.
methodsWe assessed the TBL cancer burden using data from the Global Burden of Disease (GBD) database, including 21 regions, 195 countries, and territories in the diagnostic period 1990-2017. The data of TBL cancer-related mortality and DALYs attributable to all known risk factors were also analyzed. Age-standardized rates (ASRs) and their estimated annual percentage changes (EAPCs) were calculated.
resultsIncident cases, deaths, and DALYs of TBL cancer increased worldwide (100.44%, 82.30%, and 61.27%, respectively). The age-standardized incidence rate (ASIR) was stable (EAPC = 0.02, 95% confidence interval [CI] - 0.03 to 0.08), but the age-standardized death (EAPC = - 0.34, 95%CI - 0.38 to - 0.3) and DALY rate decreased generally (EAPC = - 0.74, 95%CI - 0.8 to - 0.68). However, the change trend of ASIR and ASDR among sexes was on the contrary. China and the USA always had the highest incidence, mortality, and DALYs of TBL cancer. Significant positive correlations between ASRs and SDI were observed, especially among females. High (36.86%), high-middle (28.78%), and middle SDI quintiles (24.91%) carried the majority burden of TBL cancer. Tobacco remained the top cause of TBL cancer death and DALYs, followed by air pollution, the leading cause in the low-middle and low-SDI quintiles. Metabolic risk-related TBL cancer mortality and DALYs among females increased but was stable among males. The main ages of TBL cancer onset and death were > 50 years, and the DALYs concentrated in 50 - 69 years.
conclusionsTo significantly reduce the growing burden of TBL cancer, treatment resources need to be skewed according to factors such as risks and geography, especially for high-risk groups and high-burden areas. Asia had the greatest TBL cancer burden, followed by high-income North America. Tobacco remains the leading cause of death and DALYs, followed by air pollution. Effective prevention measures against tobacco and air pollution should be strengthened.
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