Evidence map›Paper›PMID 32689931›Full record

ReviewBMC microbiology2020

Redox control in the pathophysiology of influenza virus infection.

Ker-Kong Chen, Moeko Minakuchi, Kenly Wuputra, Chia-Chen Ku, Jia-Bin Pan, Kung-Kai Kuo, Ying-Chu Lin, Shigeo Saito, Chang-Shen Lin, Kazunari K Yokoyama

Abstract readReview
In one paragraph

Review in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
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  9. The virucidal potential effects of violet-blue light on influenza D virus.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  10. Antioxidants (Basel, Switzerland) · 2025
    Article
  11. Review
  12. Article
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  14. Review
  15. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ker-Kong ChenSchool of Dentistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
Moeko MinakuchiWaseda Research Institute for Science and Engineering, Waseca University, Shinjuku, Tokyo, 162-8480, Japan.
Kenly WuputraGraduate Institute of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., San-Ming District, Kaohsiung, 80807, Taiwan.
Chia-Chen KuGraduate Institute of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., San-Ming District, Kaohsiung, 80807, Taiwan.
Jia-Bin PanGraduate Institute of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., San-Ming District, Kaohsiung, 80807, Taiwan.
Kung-Kai KuoDepartment Surgery, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan.
Ying-Chu LinSchool of Dentistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
Shigeo SaitoWaseda Research Institute for Science and Engineering, Waseca University, Shinjuku, Tokyo, 162-8480, Japan.
Chang-Shen LinGraduate Institute of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., San-Ming District, Kaohsiung, 80807, Taiwan. changshenlin@gmail.com.
Kazunari K YokoyamaWaseda Research Institute for Science and Engineering, Waseca University, Shinjuku, Tokyo, 162-8480, Japan. kazu@kmu.edu.tw.ORCID 0000-0001-8508-7587

Funding

Kaohsiung Medical University KMU-TC108A02 and SA10803CMinistry of Science and Technology, Taiwan MOST-107-2314-B-037-026Ministry of Science and Technology, Taiwan MOST-108-2320-B-037-005National Health Research Institutes NHRI-EX108-10720SI
6 · The paper itself

Abstract

Triggered in response to external and internal ligands in cells and animals, redox homeostasis is transmitted via signal molecules involved in defense redox mechanisms through networks of cell proliferation, differentiation, intracellular detoxification, bacterial infection, and immune reactions. Cellular oxidation is not necessarily harmful per se, but its effects depend on the balance between the peroxidation and antioxidation cascades, which can vary according to the stimulus and serve to maintain oxygen homeostasis. The reactive oxygen species (ROS) that are generated during influenza virus (IV) infection have critical effects on both the virus and host cells. In this review, we outline the link between viral infection and redox control using IV infection as an example. We discuss the current state of knowledge on the molecular relationship between cellular oxidation mediated by ROS accumulation and the diversity of IV infection. We also summarize the potential anti-IV agents available currently that act by targeting redox biology/pathophysiology.

Indexed as

AnimalsAntiviral AgentsCell DifferentiationCell ProliferationHomeostasisHumansInfluenza A virusInfluenza, HumanOrthomyxoviridae InfectionsOxidation-ReductionReactive Oxygen SpeciesSignal TransductionAntiviral AgentsReactive Oxygen SpeciesAntioxidationAryl hydrocarbon receptorCellular oxidationNuclear factor E2-related factor 2Reactive oxygen species

Identifiers

PMID32689931
PMCPMC7370268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.