Evidence map›Paper›PMID 32689849›Full record

Trial reportThe Journal of international medical research2020

Assessment of two prophylactic fluid strategies in aneurysmal subarachnoid hemorrhage: A randomized trial.

Judit Gál, Béla Fülesdi, Dávid Varga, Babett Fodor, Eszter Varga, Péter Siró, Dániel Bereczki, Sándor Szabó, Csilla Molnár

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02064075 (Phase 4 Prospective, Randomized, Blinded Study on the Effect of Different Hydration Strategies on Mortality and Changes in Quality of Life of Patients Suffering From Subarachnoid Haemorrhage), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02064075 phase4completednot on this map

Phase 4 Prospective, Randomized, Blinded Study on the Effect of Different Hydration Strategies on Mortality and Changes in Quality of Life of Patients Suffering From Subarachnoid Haemorrhage

TypeinterventionalSponsorUniversity of DebrecenRan2013 to 2013Enrolled96ConditionsSubarachnoid HemorrhageArmsLactated Ringer's solution, Hydroxyethyl starch
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Judit GálDepartment of Anesthesiology and Intensive Care, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.
Béla FülesdiDepartment of Anesthesiology and Intensive Care, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.ORCID https://orcid.org/0000-0003-2541-9740
Dávid VargaDepartment of Anesthesiology and Intensive Care, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.
Babett FodorDepartment of Anesthesiology and Intensive Care, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.
Eszter VargaDepartment of Anesthesiology and Intensive Care, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.
Péter SiróDepartment of Anesthesiology and Intensive Care, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.
Dániel BereczkiDepartment of Neurology Semmelweis University, Budapest, Hungary.
Sándor SzabóDepartment of Neurosurgery, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.
Csilla MolnárDepartment of Anesthesiology and Intensive Care, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.
University of Debrecen · HUSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the effect of two prophylactic euvolemic fluid strategy regimens on the incidence of cerebral vasospasm and clinical outcomes in patients with aneurysmal subarachnoid hemorrhage (SAH).

methodsNinety-six patients with a basal intravenous intake of 15 mL/kg/day of Ringer's lactate solution were included, and an additional 15 to 50 mL/kg/day Ringer's lactate (RL-group) or hydroxyethyl starch 130/0.4 solution (HES-group) was administered to maintain the targeted mean arterial pressure. The primary end point was the occurrence of cerebral vasospasm during the first 14 days. The secondary end points were case fatality, Barthel's index, and Glasgow Outcome Scores (GOS) at 30 days after SAH.

resultsCerebral vasospasm developed in 42 patients (43.7%), and nine of these events were severe. The vasospasm rate among the RL- and HES-based groups was 25/48 and 17/48, respectively. For the secondary endpoint, four patients (4%) died by the end of follow-up (two in each group). Unfavorable outcome cases were not different in the RL and HES groups (9 vs. 14, respectively). There was no difference between the Barthel's scores at 30 days between the two groups.

conclusionsUsing starches in a prophylactic treatment strategy in aneurysmal SAH in not supported by the study.The trial was registered at Clinicaltrials.gov under the number NCT02064075.

Indexed as

Subarachnoid HemorrhageVasospasm, IntracranialHumansTreatment OutcomeVasoconstrictionAneurysmal subarachnoid hemorrhageBarthel’s indexcerebral vasospasmeuvolemicGlasgow outcome scorehydroxyethyl starchprophylactic fluid strategy

Identifiers

PMID32689849
PMCPMC7375726
OpenAlexW3044557226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.