Evidence map›Paper›PMID 32689841›Full record

ArticleJDR clinical and translational research2021

Characterizing Microbiota from Sjögren's Syndrome Patients.

M Singh, F Teles, N G Uzel, A Papas

Open access · greenAbstract read
In one paragraph

Article in JDR clinical and translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. [Isolation, identification, and metabolic characterization of aBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Positive Role of Saliva in the Oral Microbiome.Advances in experimental medicine and biology · 2025
    Review
  12. Frontiers in cellular and infection microbiology · 2025
    Article
  13. Review
  14. The Oral Microbial Ecosystem in Age-Related Xerostomia: A Critical Review.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. The oral microbiome in autoimmune diseases: friend or foe?Journal of translational medicine · 2023
    Review
  20. High-Throughput Sequencing of Oral Microbiota inJournal of clinical medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M SinghDivision of Oral Medicine, School of Dental Medicine, Tufts University, Boston, MA, USA.
F TelesDepartment of Basic and Translational Sciences, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA, USA.
N G UzelDepartment of Periodontology, School of Dental Medicine, Tufts University, Boston, MA, USA.
A PapasDivision of Oral Medicine, School of Dental Medicine, Tufts University, Boston, MA, USA.
Tufts University · USCenter for Innovation · US

Funding

Intra-Oral Biofilm FormationR01DE014368 · NIDCR · FORSYTH INSTITUTE · PI SOCRANSKY, SIGMUND S · 2002 to 2004
$1.7M
Targeted Cultivation of New Periodontal PathogensR01DE024767 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TELES, FLAVIA ROCHA · 2015 to 2018
$1.6M
NIDCR NIH HHS R01 DE014368NIDCR NIH HHS R01 DE024767
6 · The paper itself

Abstract

objectiveTo compare the oral microbiota of Sjögren's syndrome (SS) with that of healthy subjects (HS).

methodsSupragingival and subgingival biofilm samples were collected from the mesial-buccal tooth surfaces of SS patients (n = 57) and age- and sex-matched HS (n = 53). Unstimulated saliva and 8 oral tissue samples were taken using a buccal brush. Caries and periodontal measures were recorded. All supragingival samples and a subgroup of 24 SS and 28 HS subgingival samples, as well as 32 SS and 11 HS saliva and oral tissue samples, were analyzed for their content of 41 bacterial species using checkerboard DNA-DNA hybridization. Mean levels (×10

resultsMean (×10

conclusionThese findings indicate that saliva is a major controlling factor of intraoral biofilm. V. parvula may be a unique microbial biomarker for Sjögren's syndrome. KNOWLEDGE TRANSFER STATEMENT: The microbiome characterized for Sjögren's syndrome in salivary hypofunction is shown to be under stress and reduced. Veillonella parvula can be a possible identification of a biomarker for Sjögren's syndrome.

Indexed as

Dental PlaqueMicrobiotaSjogren's SyndromeColony Count, MicrobialDNA, BacterialHumansVeillonellaDNA, Bacterialbulk fluidDNA-DNA hybridizationmean and percentages of DNA countplaquesalivary hypofunctionVeillonella parvula

Identifiers

PMID32689841
PMCPMC8209841
OpenAlexW3044315192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.