Evidence map›Paper›PMID 32688367›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020

Mechanisms associated with the antidepressant-like effects of L-655,708.

Vladislav Bugay, Alexandra Maxine McCoy, Daniel James Lodge, Robert Brenner, Alan Frazer, Flavia Regina Carreno

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. αJournal of psychopharmacology (Oxford, England) · 2026
    Article
  3. Review
  4. Article
  5. GABATrends in pharmacological sciences · 2023
    Review
  6. Hippocampal α5-GABABiological psychiatry global open science · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vladislav BugayDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center, San Antonio, TX, USA.
Alexandra Maxine McCoyDepartment of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA.
Daniel James LodgeDepartment of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-6772-1748
Robert BrennerDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center, San Antonio, TX, USA.
Alan FrazerDepartment of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA.
Flavia Regina CarrenoDepartment of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA. Carrenof@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · US

Funding

Integrated Graduate Training Program in Neuroscience, UTHSCSAT32NS082145 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI David A Morilak · 2013 to 2026
$1.5M
Novel mechanisms contributing to the antidepressant-like response of pharmacological hippocampal activationR21MH113899 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CARRENO, FLAVIA · 2018 to 2019
$419k
A novel mouse model for anxiety-induced seizuresR03NS114906 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BRENNER, ROBERT · 2020 to 2020
$231k
Selective negative allosteric modulators of alpha 5-GABAA receptors: novel psychotherapeutic drugsI01BX000559 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI MORILAK, DAVID A · 2011 to 2025
–
BLRD VA I01 BX000559BLRD VA I01 BX004693NIMH NIH HHS R21 MH113899NINDS NIH HHS R03 NS114906NINDS NIH HHS T32 NS082145
6 · The paper itself

Abstract

Previous research has demonstrated that selective modulation of hippocampal transmission by systemic administration of an α5-GABA

Indexed as

Antidepressive AgentsKetamineAnimalsHippocampusImidazolesRatsAntidepressive AgentsImidazolesKetamineL 655,708

Identifiers

PMID32688367
PMCPMC7785005
OpenAlexW3043710962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.