Evidence map›Paper›PMID 32688249›Full record

ReviewCurrent opinion in genetics & development2020

Cortico-basal ganglia circuits underlying dysfunctional control of motor behaviors in neuropsychiatric disorders.

Ana Mafalda Vicente, Gabriela J Martins, Rui M Costa

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

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  9. Disuse-driven plasticity in the human thalamus and putamen.bioRxiv : the preprint server for biology · 2024
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  18. Preserved Motility after Neonatal Dopaminergic Lesion Relates to Hyperexcitability of Direct Pathway Medium Spiny Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ana Mafalda VicenteDepartments of Neuroscience and Neurology, Zuckerman Mind Brain Institute, Columbia University 3227 Broadway, New York, NY, 10027, United States.
Gabriela J MartinsDepartments of Neuroscience and Neurology, Zuckerman Mind Brain Institute, Columbia University 3227 Broadway, New York, NY, 10027, United States.
Rui M CostaDepartments of Neuroscience and Neurology, Zuckerman Mind Brain Institute, Columbia University 3227 Broadway, New York, NY, 10027, United States. Electronic address: rc3031@columbia.edu.
Columbia University · US

Funding

Modeling multi-area dynamics during motor controlU19NS104649 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSTA, RUI M., WOLPERT, DANIEL · 2017 to 2021
$15.3M
NINDS NIH HHS U19 NS104649
6 · The paper itself

Abstract

Neuropsychiatric disorders often manifest with abnormal control of motor behavior. Common symptoms include restricted and repetitive patterns of behavior (RRBs). Cortico-basal ganglia circuits have been implicated in the etiology of RBBs. However, there is a vast range of behaviors encompassed in RRBs, from simple explosive motor tics to rather complex ritualized compulsions. In this review, we highlight how recent findings about the function of specific basal ganglia circuits can begin to shed light into defined motor symptoms associated with neuropsychiatric disorders. We discuss recent studies using genetic animal models that advocate that different aspects of motor repetition in neurodevelopmental disorders, like obsessive-compulsive disorder and autism spectrum disorder, emerge from particular dysregulations in distinct cortico-basal ganglia circuits.

Indexed as

AnimalsBasal GangliaHumansMental DisordersMotor DisordersNeural PathwaysPrefrontal Cortex

Identifiers

PMID32688249
PMCPMC7749078
OpenAlexW3043637404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.