ArticleNeurobiology of aging2020
Right hippocampal volume mediation of subjective memory complaints differs by hypertension status in healthy aging.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Preventive Effect of Hippocampal Sparing on Cognitive Dysfunction of Patients Undergoing Whole-Brain Radiotherapy and Imaging Assessment of Hippocampal Volume Changes.BioMed research international · 2022Trial
- Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging.npj aging · 2025Article
- Regional covariance of white matter hyperintensity volume patterns associated with hippocampal volume in healthy aging.Frontiers in aging neuroscience · 2024Article
- A Mixed-Effects Model of Associations Between Interleukin-6 and Hippocampal Volume.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- BMI and Allostatic Load Are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light among Urban Middle-Aged Adults.The Journal of nutrition · 2022Article
- Article
- Subjective cognitive decline symptoms and its association with socio-demographic characteristics and common chronic diseases in the southern Chinese older adults.BMC public health · 2022Article
- Hypertension Status Moderated the Relationship between the Hippocampal Subregion of the Left GC-ML-DG and Cognitive Performance in Subjective Cognitive Decline.Disease markers · 2022Article
- Influence of regional white matter hyperintensity volume and apolipoprotein E ε4 status on hippocampal volume in healthy older adults.Hippocampus · 2021Article
- How Well Does Subjective Cognitive Decline Correspond to Objectively Measured Cognitive Decline? Assessment of 10-12 Year Change.Journal of Alzheimer's disease : JAD · 2021Article
- Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2021Article
- Age-Related Regional Network Covariance of Magnetic Resonance Imaging Gray Matter in the Rat.Frontiers in aging neuroscience · 2020Article
- Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults.Frontiers in aging neuroscience · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Subjective memory complaints (SMCs) may be an important early indicator of cognitive aging and preclinical Alzheimer's disease risk. This study investigated whether age-related differences in right or left hippocampal volume underlie SMCs, if these relationships differ by hypertension status, and how they are related to objective memory performance in a group of 190 healthy older adults, 50-89 years of age. Analyses revealed a significant mediation of the relationship between age and mild SMCs by right hippocampal volume that was moderated by hypertension status. This moderated mediation effect was not observed with left hippocampal volume. Additionally, a moderated serial mediation model showed that age predicted right hippocampal volume, which predicted SMCs, and in turn predicted objective memory performance on several measures of verbal selective reminding in individuals with hypertension, but not in non-hypertensives. Together, these findings suggest that even mild SMCs, in the context of hypertension, provide an early indicator of cognitive aging, reflecting a potential link among vascular risk, SMCs, and the preclinical risk for Alzheimer's disease.
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