Evidence map›Paper›PMID 32688071›Full record

ArticleDrug and alcohol dependence2020

The reinforcing effects of ethanol within the prelimbic cortex and ethanol drinking: Involvement of local dopamine D

Eric A Engleman, Cynthia M Ingraham, Zachary A Rodd, James M Murphy, William J McBride, Zheng-Ming Ding

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Ethanol drinking involves astrocytes in male Wistar rats.bioRxiv : the preprint server for biology · 2026
    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eric A EnglemanDepartment of Psychiatry, Indiana University School of Medicine, 355 West 16th Street, Indianapolis, IN 46202, United States.
Cynthia M IngrahamDepartment of Psychiatry, Indiana University School of Medicine, 355 West 16th Street, Indianapolis, IN 46202, United States.
Zachary A RoddDepartment of Psychiatry, Indiana University School of Medicine, 355 West 16th Street, Indianapolis, IN 46202, United States.
James M MurphyDepartment of Psychiatry, Indiana University School of Medicine, 355 West 16th Street, Indianapolis, IN 46202, United States.
William J McBrideDepartment of Psychiatry, Indiana University School of Medicine, 355 West 16th Street, Indianapolis, IN 46202, United States.
Zheng-Ming DingDepartment of Psychiatry, Indiana University School of Medicine, 355 West 16th Street, Indianapolis, IN 46202, United States; Department of Anesthesiology and Perioperative Medicine, Department of Pharmacology, Pennsylvania State University College of Medicine, 700 HMC Crescent Road, Hershey, PA 17033, United States. Electronic address: zding@pennstatehealth.psu.edu.
Indiana University School of MedicinePennsylvania State University · US

Funding

Translational Research and Science Education (OUT)P60AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI DAVID A. KAREKEN · 2003 to 2026
$45.5M
CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOLR01AA012262 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MCBRIDE, WILLIAM J · 2000 to 2016
$4.3M
Role of Cotinine in Nicotine Use Disorders: Alzheimer's SupplementR01DA044242 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DING, ZHENG-MING · 2017 to 2021
$2.5M
CNS SITES MEDIATING ALCOHOL DRINKING BEHAVIORR01AA010717 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MURPHY, JAMES M · 1995 to 2010
$2.4M
Consequences of voluntary intake of ethanol & nicotine during peri-adolescenceR01AA020396 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI BELL, RICHARD LOWELL, ENGLEMAN, ERIC A. · 2012 to 2016
$1.2M
NIAAA NIH HHS P60 AA007611NIAAA NIH HHS R01 AA010717NIAAA NIH HHS R01 AA012262NIAAA NIH HHS R01 AA020396NIDA NIH HHS R01 DA044242
6 · The paper itself

Abstract

Previous studies have identified important mesolimbic regions in supporting the reinforcing effects of ethanol. However, the involvement of the medial prefrontal cortex (mPFC), another key region within the mesocorticolimbic system, in ethanol reinforcement has been understudied. The objective of the current study was to examine the role of the prelimbic (PL) cortex sub-region of the mPFC in ethanol reinforcement and drinking. Intracranial self-administration was used to examine the reinforcing effects of ethanol within the PL cortex. Quantitative microdialysis was used to measure basal extracellular DA concentrations and clearance in the PL cortex following chronic ethanol drinking. In addition, the involvement of dopamine (DA) D

Indexed as

Alcohol DrinkingAnimalsDopamineEthanolMaleMicrodialysisPrefrontal CortexReceptors, DopamineReinforcement, PsychologySelf AdministrationSulpirideSynaptic TransmissionDopamineEthanolReceptors, DopamineSulpirideD(2) receptorDopamineEthanolIntra-cranial self-administrationMedial prefrontal cortexNo-net-flux microdialysis

Identifiers

PMID32688071
PMCPMC7431019
OpenAlexW3040472821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.