Evidence map›Paper›PMID 32688025›Full record

ArticleBrain, behavior, and immunity2020

Prenatal stress increases IgA coating of offspring microbiota and exacerbates necrotizing enterocolitis-like injury in a sex-dependent manner.

Kyle M Brawner, Venkata A Yeramilli, Bethany A Kennedy, Riddhi K Patel, Colin A Martin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  18. Intestinal Homeostasis under Stress Siege.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kyle M BrawnerDivision of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: kbrawner@uab.edu.
Venkata A YeramilliDivision of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Bethany A KennedyDivision of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Riddhi K PatelDivision of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Colin A MartinDivision of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

Short-Term Research Experiences Advancing Medical Students (STREAMS)T35DK116670 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HERBERT CHEN, Daniel I Chu · 2019 to 2026
$371k
NIDDK NIH HHS T35 DK116670
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is an intestinal inflammatory disease with high morbidity and mortality that affects almost exclusively premature infants. Breast milk feeding is known to substantially lower NEC incidence, and specific components of breast milk, such as immunoglobulin (Ig) A, have been identified as mediating this protective effect. On the other hand, accumulating evidence suggests dysbiosis of the neonatal intestinal microbiome contributes to NEC pathogenesis. In mice, neonates can inherit a dysbiotic microbiome from dams that experience stress during pregnancy. Here we show that while prenatal stress lowers fecal IgA levels in pregnant mice, it does not result in lower levels of IgA in the breast milk. Nevertheless, coating of female, but not male, offspring microbiota by IgA is increased by prenatal stress. Accordingly, prenatal stress was found to alter the bacterial community composition in female neonates but not male neonates. Furthermore, female, but not male, offspring of prenatally stressed mothers exhibited more severe colonic tissue damage in a NEC-like injury model compared to offspring with non-stressed mothers. Our results point to prenatal stress as a possible novel risk factor for NEC and potentially reveal new avenues in NEC prevention and therapy.

Indexed as

Enterocolitis, NecrotizingAnimalsDysbiosisFemaleImmunoglobulin AMiceMicrobiotaImmunoglobulin ACorticosteroneIgAMicrobiomeNecrotizing enterocolitisStress

Identifiers

PMID32688025
PMCPMC7919389
OpenAlexW3042453024

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.