Evidence map›Paper›PMID 32687993›Full record

ReviewCurrent opinion in cell biology2020

Mechanobiology of neural development.

Hamid Abuwarda, Medha M Pathak

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Non-transport functions of motor proteins in corticogenesis.Frontiers in cell and developmental biology · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Frontiers in psychology · 2025
    Article
  11. Article
  12. Review
  13. Mechanically guided cell fate determination in early development.Cellular and molecular life sciences : CMLS · 2024
    Review
  14. Article
  15. Article
  16. Piezo1: the key regulators in central nervous system diseases.Frontiers in cellular neuroscience · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hamid AbuwardaDepartment of Physiology & Biophysics, UC Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA, USA.
Medha M PathakDepartment of Physiology & Biophysics, UC Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA, USA; Center for Complex Biological Systems, UC Irvine, Irvine, CA, USA; Department of Biomedical Engineering, UC Irvine, Irvine, CA, USA. Electronic address: medhap@uci.edu.
UC Irvine Health · USUniversity of California, Irvine · US

Funding

Building the brain: How mechanical forces shape human neural developmentDP2AT010376 · NCCIH · UNIVERSITY OF CALIFORNIA-IRVINE · PI PATHAK, MEDHA M · 2018 to 2020
$2.9M
Piezo1 in neural stem cell mechano-regulationR01NS109810 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PATHAK, MEDHA M · 2018 to 2022
$2.2M
NCCIH NIH HHS DP2 AT010376NINDS NIH HHS R01 NS109810
6 · The paper itself

Abstract

As the brain develops, proliferating cells organize into structures, differentiate, migrate, extrude long processes, and connect with other cells. These biological processes produce mechanical forces that further shape cellular dynamics and organ patterning. A major unanswered question in developmental biology is how the mechanical forces produced during development are detected and transduced by cells to impact biochemical and genetic programs of development. This gap in knowledge stems from a lack of understanding of the molecular players of cellular mechanics and an absence of techniques for measuring and manipulating mechanical forces in tissue. In this review article, we examine recent advances that are beginning to clear these bottlenecks and highlight results from new approaches that reveal the role of mechanical forces in neurodevelopmental processes.

Indexed as

BiophysicsAnimalsBiomechanical PhenomenaBrainHumansMechanotransduction, CellularNeural CrestNeural Stem CellsBiomechanicsBrain morphogenesisDevelopmental biologyMechanical forcesMechanotransductionNeural development

Identifiers

PMID32687993
PMCPMC7578076
OpenAlexW3043091645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.