Evidence map›Paper›PMID 32687653›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy.

Bingbing Sun, Rui Chang, Shoupeng Cao, Chengqian Yuan, Luyang Zhao, Haowen Yang, Junbai Li, Xuehai Yan, Jan C M van Hest

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 202 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Article
  7. Activatable Photosensitizers: From Fundamental Principles to Advanced Designs.Angewandte Chemie (International ed. in English) · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. A Nanographene-Porphyrin Hybrid for Near-Infrared-Ii Phototheranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  12. Review
  13. Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Bingbing SunBio-Organic Chemistry, Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.ORCID 0000-0002-9934-1248
Rui ChangState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Shoupeng CaoBio-Organic Chemistry, Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Chengqian YuanState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Luyang ZhaoState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Haowen YangLaboratory of Immunoengineering, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.ORCID 0000-0002-3196-8917
Junbai LiBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.ORCID 0000-0001-9575-3125
Xuehai YanState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.ORCID 0000-0002-0890-0340
Jan C M van HestBio-Organic Chemistry, Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.ORCID 0000-0001-7973-2404
Eindhoven University of Technology · NLInstitute of Process Engineering · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inspired by the dynamic morphology control of molecular assemblies in biological systems, we have developed pH-responsive transformable peptide-based nanoparticles for photodynamic therapy (PDT) with prolonged tumor retention times. The self-assembled peptide-porphyrin nanoparticles transformed into nanofibers when exposed to the acidic tumor microenvironment, which was mainly driven by enhanced intermolecular hydrogen bond formation between the protonated molecules. The nanoparticle transformation into fibrils improved their singlet oxygen generation ability and enabled high accumulation and long-term retention at tumor sites. Strong fluorescent signals of these nanomaterials were detected in tumor tissue up to 7 days after administration. Moreover, the peptide assemblies exhibited excellent anti-tumor efficacy via PDT in vivo. This in situ fibrillar transformation strategy could be utilized to design effective stimuli-responsive biomaterials for long-term imaging and therapy.

Indexed as

AcidsHumansHydrogen-Ion ConcentrationNanostructuresPeptidesPhotochemotherapyPhotosensitizing AgentsPorphyrinsSpectrum AnalysisTumor MicroenvironmentAcidsPeptidesPhotosensitizing AgentsPorphyrinsfibrillar transformationpeptidesphotodynamic therapyphotosensitizersself-assembly

Identifiers

PMID32687653
PMCPMC7693186
OpenAlexW3042493578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.