Evidence map›Paper›PMID 32687544›Full record

ArticlePloS one2020

Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB).

Tadashi Sofue, Naoki Nakagawa, Eiichiro Kanda, Hajime Nagasu, Kunihiro Matsushita, Masaomi Nangaku, Shoichi Maruyama, Takashi Wada, Yoshio Terada, Kunihiro Yamagata and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 2 countries.

Tadashi SofueDivision of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University, Kagawa, Japan.ORCID 0000-0003-1136-8532
Naoki NakagawaDivision of Cardiology, Nephrology, Respiratory and Neurology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.ORCID 0000-0002-5398-3667
Eiichiro KandaMedical Science, Kawasaki Medical School, Kurashiki, Japan.
Hajime NagasuDepartment of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Japan.
Kunihiro MatsushitaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Masaomi NangakuDivision of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Shoichi MaruyamaDivision of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takashi WadaDivision of Nephrology, Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.
Yoshio TeradaDepartment of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kochi, Japan.
Kunihiro YamagataDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Ichiei NaritaDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Motoko YanagitaDepartment of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hitoshi SugiyamaDepartment of Human Resource Development of Dialysis Therapy for Kidney Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Takashi ShigematsuDivision of Nephrology, Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
Takafumi ItoDivision of Nephrology, Faculty of Medicine, Shimane University, Izumo, Japan.
Kouichi TamuraDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID 0000-0002-0660-5372
Yoshitaka IsakaDepartment of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
Hirokazu OkadaDepartment of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Kazuhiko TsuruyaDepartment of Integrated Therapy for Chronic Kidney Disease, Kyushu University, Fukuoka, Japan.
Hitoshi YokoyamaDepartment of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa, Japan.
Naoki NakashimaDepartment of Advanced Information Technology, Kyushu University, Fukuoka, Japan.
Hiromi KataokaFaculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Japan.
Kazuhiko OheDepartment of Healthcare Information Management, The University of Tokyo Hospital, Tokyo, Japan.
Mihoko OkadaInstitute of Health Data Infrastructure for All, Tokyo, Japan.
Naoki KashiharaDepartment of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Japan.
Kawasaki Medical School · JPKyushu University · JPAsahikawa Medical University · JPJohns Hopkins University · USKagawa University · JPKanazawa Medical University · JPKanazawa University · JPKawasaki University of Medical Welfare · JPKōchi University · JPKyoto University · JPNagoya University · JPNiigata University · JPOkayama University · JPSaitama Medical University · JPShimane University · JPThe University of Osaka · JPThe University of Tokyo · JPUniversity of Tokyo Hospital · JPUniversity of Tsukuba · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Japan Chronic Kidney Disease Database (J-CKD-DB) is a nationwide clinical database of patients with chronic kidney disease (CKD) based on electronic health records. The objective of this study was to assess the prevalence of anemia and the utilization rate of erythropoiesis-stimulating agents (ESAs) in Japanese patients with CKD.

methodsIn total, 31,082 adult outpatients with estimated glomerular filtration rates of 5-60 ml/min/1.73 m2 in seven university hospitals were included this analysis. The proportions of patients with CKD stages G3b, G4, and G5 were 23.5%, 7.6%, and 3.1%, respectively.

resultsThe mean (standard deviation) hemoglobin level of male patients was 13.6 (1.9) g/dl, which was significantly higher than the mean hemoglobin level of female patients (12.4 (1.6) g/dl). The mean (standard deviation) hemoglobin levels were 11.4 (2.1) g/dl in patients with CKD stage G4 and 11.2 (1.8) g/dl in patients with CKD stage G5. The prevalences of anemia were 40.1% in patients with CKD stage G4 and 60.3% in patients with CKD stage G5. Logistic regression analysis showed that diagnoses of CKD stage G3b (adjusted odds ratio [95% confidence interval]: 2.32 [2.09-2.58]), G4 (5.50 [4.80-6.31]), and G5 (9.75 [8.13-11.7]) were associated with increased prevalence of anemia. The utilization rates of ESAs were 7.9% in patients with CKD stage G4 and 22.4% in patients with CKD stage G5.

conclusionsWe determined the prevalence of anemia and utilization rate of ESAs in Japanese patients with CKD using data from a nationwide cohort study.

Indexed as

Databases, FactualAnemiaCohort StudiesCross-Sectional StudiesFemaleGlomerular Filtration RateHemoglobinsHumansJapanMaleMiddle AgedPrevalenceRenal Insufficiency, ChronicHemoglobins

Identifiers

PMID32687544
PMCPMC7371174
OpenAlexW3044106575

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.