Evidence map›Paper›PMID 32687254›Full record

ArticleHuman brain mapping2020

Cannabis use in patients with early psychosis is associated with alterations in putamen and thalamic shape.

Musa Sami, James H Cole, Matthew J Kempton, Luciano Annibale, Debasis Das, Marlene Kelbrick, Savitha Eranti, Tracy Collier, Chidimma Onyejiaka, Aisling O'Neill and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Musa SamiInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.ORCID 0000-0002-4420-8618
James H ColeInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.ORCID 0000-0003-1908-5588
Matthew J KemptonInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.
Luciano AnnibaleInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.
Debasis DasLeicestershire Partnership NHS Trust, London, UK.
Marlene KelbrickNorthamptonshire Healthcare NHS Foundation Trust, Kettering, UK.
Savitha ErantiEast London Foundation Trust, London, UK.
Tracy CollierInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.
Chidimma OnyejiakaInstitute of Psychiatry Psychology and Neuroscience, London, UK.
Aisling O'NeillInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.
David J LythgoeInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.
Philip McGuireInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.
Steve C R WilliamsInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.
Sagnik BhattacharyyaInstitute of Psychiatry, Psychology and Neurosciences King's College London, London, UK.
King's College London · GBEast London NHS Foundation Trust · GBKettering University · USLeicestershire Partnership NHS Trust · GBNeurosciences Institute · US

Funding

Department of Health NIHR-CS-011-001Medical Research Council MR/P001408/1
6 · The paper itself

Abstract

Around half of patients with early psychosis have a history of cannabis use. We aimed to determine if there are neurobiological differences in these the subgroups of persons with psychosis with and without a history of cannabis use. We expected to see regional deflations in hippocampus as a neurotoxic effect and regional inflations in striatal regions implicated in addictive processes. Volumetric, T1w MRIs were acquired from people with a diagnosis psychosis with (PwP + C = 28) or without (PwP - C = 26) a history of cannabis use; and Controls with (C + C = 16) or without (C - C = 22) cannabis use. We undertook vertex-based shape analysis of the brainstem, amygdala, hippocampus, globus pallidus, nucleus accumbens, caudate, putamen, thalamus using FSL FIRST. Clusters were defined through Threshold Free Cluster Enhancement and Family Wise Error was set at p < .05. We adjusted analyses for age, sex, tobacco and alcohol use. The putamen (bilaterally) and the right thalamus showed regional enlargement in PwP + C versus PwP - C. There were no areas of regional deflation. There were no significant differences between C + C and C - C. Cannabis use in participants with psychosis is associated with morphological alterations in subcortical structures. Putamen and thalamic enlargement may be related to compulsivity in patients with a history of cannabis use.

Indexed as

AdultFemaleHumansMagnetic Resonance ImagingMaleMarijuana UsePsychotic DisordersPutamenThalamusYoung Adultcannabispsychotic disordersshape analysissubcortical shape

Identifiers

PMID32687254
PMCPMC7502838
OpenAlexW3038569960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.