Evidence map›Paper›PMID 32686950›Full record

ArticlePsychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors2021

Patterns of lapses and recoveries during a quit attempt using varenicline and behavioral counseling among smokers with and without HIV.

Rebecca L Ashare, E Paul Wileyto, Erin Logue-Chamberlain, Robert Gross, Rachel F Tyndale, Caryn Lerman, Larry W Hawk, Paul Cinciripini, Tony P George, Su Fen Lubitz and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Interventions for tobacco use cessation in people living with HIV.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Nicotine receptor partial agonists for smoking cessation.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Trial
  4. The role of alternative reinforcers in smoking outcomes among people with and without HIV.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025
    Observational
  5. Differences in Cognition and Smoking Abstinence Rates Among People With and Without HIV Who Smoke.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Observational
  6. Article
  7. Optimizing the Implementation of Tobacco Treatment for People with HIV: A Pilot Study.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Rebecca L AshareDepartment of Psychiatry.ORCID 0000-0003-4664-009X
E Paul WileytoCenter for Clinical Epidemiology and Biostatistics.ORCID 0000-0002-4389-1128
Erin Logue-ChamberlainDepartment of Psychiatry.
Robert GrossCenter for Clinical Epidemiology and Biostatistics and Division of Infectious Diseases.
Rachel F TyndaleCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Pharmacology and Toxicology, and Division of Brain and Therapeutics.ORCID 0000-0003-1297-2053
Caryn LermanUSC Norris Comprehensive Cancer Center.
Larry W HawkDepartment of Psychology.ORCID 0000-0001-6593-9746
Paul CinciripiniDepartment of Behavioral Science.
Tony P GeorgeAddictions Division, Centre for Addiction and Mental Health and Division of Brain and Therapeutics.
Su Fen LubitzDepartment of Psychiatry.
Robert SchnollDepartment of Psychiatry.ORCID 0000-0002-4089-856X
Center for Clinical Research (United States) · USCentre for Addiction and Mental Health · CAUSC Norris Comprehensive Cancer Center · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube, Kelly L Jordan-Sciutto · 2013 to 2026
$23.5M
University of Toronto Coordinating Genetics Core & Clinical Trial SiteU01DA020830 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SWAN, GARY E · 2005 to 2014
$22.4M
Neuroscience-based Interventions for Cancer Risk Behavior ChangeR35CA197461 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LERMAN, CARYN · 2015 to 2021
$6.0M
A Placebo Controlled Trial of Varenicline for Smoking among those with HIV/AIDSR01DA033681 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SCHNOLL, ROBERT ADAM · 2012 to 2016
$2.5M
A Patient-Oriented Research Mentoring Program in Tobacco Dependence ResearchK24DA045244 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Robert Adam Schnoll · 2018 to 2026
$1.7M
Canada Research Chair in PharmacogenomicsCentre for Addiction and Mental HealthCIHRNCI NIH HHSNCI NIH HHS R35 CA197461NHGRI NIH HHSNIAID NIH HHS P30 AI045008NIDA NIH HHSNIDA NIH HHS K24 DA045244NIDA NIH HHS R01 DA033681NIDA NIH HHS U01 DA020830NIGMS NIH HHSNIMH NIH HHS P30 MH097488Penn Center for AIDS ResearchPenn Mental Health AIDS Research Center
6 · The paper itself

Abstract

Addressing tobacco use among HIV+ smokers is a priority. Lack of knowledge about how HIV+ smokers respond to tobacco use treatments limits our ability to effectively treat this population of smokers. Using data from 2 clinical trials that provided 12 weeks of varenicline and behavioral counseling, 1 with smokers with HIV (n = 89) and 1 with smokers without HIV (n = 179), we used mixed logistic regression modeling to compare point-prevalence abstinence rates and adherence to the initial target quit date (TQD) and Cox regression for repeated outcomes to evaluate lapse and recovery dynamics between the groups. Sixty percent of HIV- smokers refrained from smoking at the TQD while only 33% of HIV+ smokers did (odds ratio [OR] = 0.32, 95% CI [0.18, 0.56], p < .001). The point-prevalence abstinence rates at Week 12 were 31% (HIV-) and 28% (HIV+; OR = 0.7, 95% CI [0.42, 1.16], p = .16) and the point prevalence abstinence rates at Week 24 were 22% (HIV-) and 15% (HIV+; OR = 0.87, 95% CI [0.49, 1.57], p = .65). Although there was no interaction between HIV status and lapse risk, χ2(3) < 1, there was a significant interaction for the recovery model, (χ2(3) = 20.4, p < 0.001): as the number of events increased, the time to the next recovery became longer among smokers with HIV, compared to smokers without HIV. Although HIV+ smokers were treated effectively with varenicline, compared to HIV- smokers, they showed significantly lower initial cessation at the TQD and took increasingly longer to recover following lapses. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Indexed as

HIV InfectionsSmoking CessationCounselingHumansSmokersTreatment OutcomeVareniclineVarenicline

Identifiers

PMID32686950
PMCPMC7855008
OpenAlexW3044695930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.