Evidence map›Paper›PMID 32686913›Full record

ArticlePhysiological reports2020

Prominin-1-expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury.

Michael Fenlon, Celia Short, Jiabo Xu, Nicolas Malkoff, Elaa Mahdi, Michelle Hough, Alison Glazier, Calvin Lee, Kinji Asahina, Kasper S Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michael FenlonDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Celia ShortDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Jiabo XuDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Nicolas MalkoffDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Elaa MahdiDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Michelle HoughDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Alison GlazierDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Calvin LeeDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Kinji AsahinaSouthern California Research Center for ALPD & Cirrhosis, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kasper S WangDevelopmental Biology, Regenerative Medicine, and Stem Cell Program, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-0487-6416
Children's Hospital of Los Angeles · USUniversity of Southern California · US

Funding

Limited Competition for the Continuation of the Childhood Liver Disease Research Network (ChilLDRen) Clinical Centers.U01DK084538 · NIDDK · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KOHLI, ROHIT · 2009 to 2023
$4.8M
Dissection of Glisson's capsule in alcohol induced liver injuryR21AA024840 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ASAHINA, KINJI · 2016 to 2017
$433k
NIAAA NIH HHS AA024840NIAAA NIH HHS R21 AA024840NIDDK NIH HHS DK084538NIDDK NIH HHS U01 DK084538
6 · The paper itself

Abstract

Cholestatic liver injury is associated with intrahepatic biliary fibrosis, which can progress to cirrhosis. Resident hepatic progenitor cells (HPCs) expressing Prominin-1 (Prom1 or CD133) become activated and participate in the expansion of cholangiocytes known as the ductular reaction. Previously, we demonstrated that in biliary atresia, Prom1(+) HPCs are present within developing fibrosis and that null mutation of Prom1 significantly abrogates fibrogenesis. Here, we hypothesized that these activated Prom1-expressing HPCs promote fibrogenesis in cholestatic liver injury. Using Prom1

Indexed as

AC133 AntigenAnimalsBile DuctsCholestasisDisease Models, AnimalFemaleFibrosisGene Knock-In TechniquesHepatocytesLiver DiseasesMaleMiceMice, Inbred C57BLMyofibroblastsStem CellsTranscription FactorsAC133 AntigenProm1 protein, mouseTranscription FactorsBiliary atresiacell lineage tracingcholangiocytecholestasisliver fibrosisRNA-seq

Identifiers

PMID32686913
PMCPMC7370750
OpenAlexW3044543610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.