Evidence map›Paper›PMID 32686874›Full record

Trial reportFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Platelet function in stroke/transient ischemic attack patients treated with tocotrienol.

Andrew Slivka, Cameron Rink, David Paoletto, Chandan K Sen

Open access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew SlivkaDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Cameron RinkDepartment of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
David PaolettoDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Chandan K SenDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID 0000-0003-3151-5202
The Ohio State University Wexner Medical Center · US

Funding

Vitamin E Neuroprotection: Novel Molecular MechanismsR01NS042617 · NINDS · OHIO STATE UNIVERSITY · PI SEN, CHANDAN K · 2002 to 2021
$3.9M
NINDS NIH HHS R01 NS042617
6 · The paper itself

Abstract

The purpose of this study was to characterize the effects of tocotrienol form of vitamin E (TCT) on platelet function in patients with stroke or transient ischemic attack (TIA). A double blind, randomized, single center phase II clinical trial was conducted comparing placebo (PBO) and 400 and 800 mg TCT daily for a year in 150 patients with a sentinel ischemic stroke or TIA event in the prior 6 months. Platelet function was measured at baseline and then, at 3 month intervals for a year, using light transmission aggregometry. The incidence of aspirin resistance in aspirin-treated patients or platelet inhibition in patients on clopidogrel alone was compared between the three treatment groups. Results showed that in patients taking aspirin and clopidogrel, the incidence of aspirin resistance was significantly decreased from 40% in PBO-treated patients to 9% in the 400 mg TCT group and 25% in the TCT 800 mg group (P = .03). In conclusion, patients on aspirin and clopidogrel had a higher incidence of aspirin resistance than all patients treated with aspirin alone and TCT decreased the frequency of aspirin resistance in this group.

Indexed as

AdultAgedAged, 80 and overAspirinClopidogrelDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationFemaleHumansIschemic Attack, TransientMaleMiddle AgedOutcome Assessment, Health CarePlatelet AggregationPlatelet Aggregation InhibitorsAspirinClopidogrelPlatelet Aggregation InhibitorsTocotrienolsVitaminsaspirin resistanceclinical trialnutritionvitamin E

Identifiers

PMID32686874
PMCPMC7815323
OpenAlexW3043232782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.