Evidence map›Paper›PMID 32686825›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis.

Matthew A Spinelli, Brentton Lowery, Jennifer A Shuford, Jon Spindler, Mary F Kearney, Jenny R McFarlane, Cheryl McDonald, Hideaki Okochi, Nhi Phung, Karen Kuncze and 7 more

Abstract readCase Reports
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Matthew A SpinelliDivision of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-6368-8664
Brentton LoweryHealth Education Learning Project, Ft. Worth, Texas, USA.
Jennifer A ShufordTexas Department of State Health Services, Austin, Texas, USA.
Jon SpindlerHuman Immunodeficiency Virus Dynamics and Replication Program, National Cancer Institute/National Institutes of Health, Ft. Worth, Texas, USA.
Mary F KearneyHuman Immunodeficiency Virus Dynamics and Replication Program, National Cancer Institute/National Institutes of Health, Ft. Worth, Texas, USA.
Jenny R McFarlaneTexas Department of State Health Services, Austin, Texas, USA.
Cheryl McDonaldTexas Centers for Infectious Disease Associates, Ft. Worth, Texas, USA.
Hideaki OkochiDivision of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Nhi PhungDivision of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Karen KunczeDivision of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Kathryn JeeDivision of Pulmonary Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
DeeJay JohannessenHealth Education Learning Project, Ft. Worth, Texas, USA.
Peter L AndersonDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
Dawn K SmithDivision of Human Immunodeficiency Virus/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Patricia DefechereuxDivision of Pulmonary Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Robert M GrantDivision of Pulmonary Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Monica GandhiDivision of Human Immunodeficiency Virus, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Dynamics and Genetics of HIV Proviruses Before and During Antiretroviral TherapyZIABC011681 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEARNEY, MARY · 2016 to 2025
$9.3M
Ultrasensitive Single-Genome Sequencing to Study HIV Transmission and EvolutionZIABC011699 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEARNEY, MARY · 2016 to 2024
$7.1M
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention TrialsR01AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2012 to 2021
$5.6M
Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING-PUMA)R01AI143340 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2018 to 2026
$5.6M
Quantify the Fraction of Proviruses That Express HIV RNA to Better Understand Proviral Latency and Its ReversalZIABC011698 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEARNEY, MARY · 2016 to 2025
$5.1M
Novel approaches for quantitative assessment of adherenceR01AI122298 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ANDERSON, PETER L. · 2016 to 2020
$3.4M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
Chemoprophylaxis and HIV Host InteractionsR01AI118575 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANT, ROBERT M. · 2015 to 2019
$2.9M
PrEP Point-of-Care Brief-Intervention for Adherence among Young Men Who Have Sex with Men (PrEP2-BAY Study)K23MH122286 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPINELLI, MATTHEW A. · 2020 to 2024
$1.0M
Objective measures of adherence for later-stage ART failure in resource limited settingsR03AI152773 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2020 to 2021
$161k
BIOLOGICALLY REALISTIC NEURAL NETWORK MODELSF31MH012286 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI GREENFIELD, ELLIOT · 1998 to 2001
$41k
NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI098472NIAID NIH HHS R01 AI118575NIAID NIH HHS R01 AI122298NIAID NIH HHS R01 AI143340NIAID NIH HHS R37 AI098472NIMH NIH HHS F31 MH012286NIMH NIH HHS K23 MH122286
6 · The paper itself

Abstract

Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.

Indexed as

Anti-HIV AgentsHIV InfectionsPharmaceutical PreparationsPre-Exposure ProphylaxisEmtricitabineHIVHumansMedication AdherenceSeroconversionTenofovirAnti-HIV AgentsEmtricitabinePharmaceutical PreparationsTenofoviradherenceHIV seroconversionPrEPPrEP failuresingle-genome-sequencing

Identifiers

PMID32686825
PMCPMC8315126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.