ArticleScientific reports2020
Targeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Self-amplifying mRNA vaccine cocktail against Staphylococcus aureus: A multi-epitope immunoinformatics and structural simulation framework.World journal of microbiology & biotechnology · 2026Article
- Host-pathogen interactions during ESKAPE-mediated urinary tract infections and ventilator-associated pneumonia: a review.Folia microbiologica · 2026Review
- Biosurfactants as Stabilizers of Silver Nanoparticles: A Sustainable Approach for Antimicrobial Applications.Microorganisms · 2026Article
- Biosurfactants as next-generation antimicrobials: mechanistic insights and applications in antibiofilm strategies for combatting antimicrobial resistance.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Evaluating Anti-Journal of pharmacy & bioallied sciences · 2024Article
- Antibacterial, Antibiofilm, and Antioxidant Activities of Aqueous CrudeMicroorganisms · 2024Article
- Repression of resistance mechanisms of Pseudomonas aeruginosa: implications of the combination of antibiotics and phytoconstituents.Archives of microbiology · 2024Review
- Microbial Biosurfactants: Antimicrobial Activity and Potential Biomedical and Therapeutic Exploits.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Pharmacological and behavioral investigation of putative self-medicative plants in Budongo chimpanzee diets.PloS one · 2024Article
- Antibacterial Activity and Proposed Mode of Action of Extracts from Selected Zimbabwean Medicinal Plants againstAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Investigating the effect ofIn silico pharmacology · 2024Article
- Going Beyond Host Defence Peptides: Horizons of Chemically Engineered Peptides for Multidrug-Resistant Bacteria.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023Review
- How to approach a study in ethnopharmacology? Providing an example of the different research stages for newcomers to the field today.Pharmacology research & perspectives · 2023Review
- Structural modification of theMicrobiology (Reading, England) · 2023Article
- Study of marine microorganism metabolites: new resources for bioactive natural products.Frontiers in microbiology · 2023Review
- Phytochemical Screening and Antimicrobial Activity Evaluation of Selected Medicinal Plants in Ethiopia.Journal of experimental pharmacology · 2023Article
- Plant Spices as a Source of Antimicrobial Synergic Molecules to Treat Bacterial and Viral Co-Infections.Molecules (Basel, Switzerland) · 2022Review
- Biomedical Applications of Plant Extract-Synthesized Silver Nanoparticles.Biomedicines · 2022Review
- Development of a Critical Appraisal Tool (AIMRDA) for the Peer-Review of Studies Assessing the Anticancer Activity of Natural Products: A Step towards Reproducibility.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Cytotoxicity of Medicinal Plant Species Used by Traditional Healers in Treating People Suffering From HIV/AIDS in Uganda.Frontiers in toxicology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance poses one of the greatest threats to global health today; conventional drug therapies are becoming increasingly inefficacious and limited. We identified 16 medicinal plant species used by traditional healers for the treatment of infectious and inflammatory diseases in the Greater Mpigi region of Uganda. Extracts were evaluated for their ability to inhibit growth of clinical isolates of multidrug-resistant ESKAPE pathogens. Extracts were also screened for quorum quenching activity against S. aureus, including direct protein output assessment (δ-toxin), and cytotoxicity against human keratinocytes (HaCaT). Putative matches of compounds were elucidated via LC-FTMS for the best-performing extracts. These were extracts of Zanthoxylum chalybeum (Staphylococcus aureus: MIC: 16 μg/mL; Enterococcus faecium: MIC: 32 μg/mL) and Harungana madagascariensis (S. aureus: MIC: 32 μg/mL; E. faecium: MIC: 32 μg/mL) stem bark. Extracts of Solanum aculeastrum root bark and Sesamum calycinum subsp. angustifolium leaves exhibited strong quorum sensing inhibition activity against all S. aureus accessory gene regulator (agr) alleles in absence of growth inhibition (IC
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