ArticleNature communications2020
Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- A meta-analysis identifies driver genes and characterizes the molecular epidemiology of colorectal cancer.Scientific reports · 2026Pooled it
- Tumor Mutational Burden Predicting the Efficacy of Immune Checkpoint Inhibitors in Colorectal Cancer: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Colibactin-associated mutations in the human colon appear to reflect anatomy and early exposure, not oncogenesis.medRxiv : the preprint server for health sciences · 2026Article
- Neoantigen evolution and response to checkpoint inhibitor immunotherapy in colorectal cancer.Nature communications · 2026Article
- Semaphorin 6D drives anti-tumor type I interferon responses to reprogram the tumor microenvironment in colorectal cancer.Cell death & disease · 2026Article
- A novel Dual-guide CRISPR-Cas13 strategy improves specificity for single-nucleotide variant detection.Nucleic acids research · 2026Article
- Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features.British journal of cancer · 2026Article
- Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes.BMC cancer · 2025Article
- Colorectal cancer-associated PCBP1 mutations disrupt protein stability in a dominant negative manner.bioRxiv : the preprint server for biology · 2025Article
- A 14-Gene Panel for Predicting Colorectal Cancer Recurrence Using Circulating Tumor DNA in Different Testing Conditions.Cancer science · 2025Article
- Design of mismatch closure for enhanced specificity in DNA strand displacement reactions.Nucleic acids research · 2025Article
- Clinical Utility of Monitoring Circulating Tumor DNA Using a Targeted Next-generation Sequencing Panel in Patients with Colorectal Cancer.Annals of laboratory medicine · 2025Article
- Genomic landscape of cancer in racially and ethnically diverse populations.Nature reviews. Genetics · 2025Review
- Radioresistance in rectal cancer: can nanoparticles turn the tide?Molecular cancer · 2025Review
- The rise and evolving role ofCurrent research in microbial sciences · 2025Review
- Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids.Nature cancer · 2024Article
- Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.The American journal of clinical nutrition · 2024Article
- Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Clinical and molecular heterogeneity associated with tumor sidedness in colorectal liver metastasis: a multicenter propensity cohort study.Hepatobiliary surgery and nutrition · 2024Article
- Incorporating Novel Technologies in Precision Oncology for Colorectal Cancer: Advancing Personalized Medicine.Cancers · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
76 authors at 20 institutions in 7 countries.
Syed H Zaidi *Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Tabitha A Harrison *Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0002-4173-7530
Amanda I Phipps *Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Robert SteinfelderPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Quang M TrinhOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.ORCID http://orcid.org/0000-0002-3602-2290
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Barbara L BanburyPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Peter GeorgesonColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-5096-4735
Catherine S GrassoPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Marios GiannakisDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Jeremy B AdamsOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Elizabeth AlwersDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Efrat L AmitayDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8585-7622
Richard T BarfieldPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Ivan BorozanOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.ORCID http://orcid.org/0000-0002-3145-3550
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Stefanie BrezinaInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschekagasse 8a, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0001-5238-6900
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-2225-6675
Yin CaoClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, 02114, USA.
Andrew T ChanBroad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA.ORCID http://orcid.org/0000-0001-7284-6767
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8919-1971
Charles M ConnollyPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
David A DrewClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, 02114, USA.
Alton Brad FarrisPathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Rd. NE, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0001-5534-7763
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
Amy J FrenchDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Charles S FuchsYale Cancer Center, 333 Cedar St, New Haven, CT, 06510, USA.
Levi A GarrawayDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Steve GruberDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, 90089, USA.
Mark A GuinterBehavioral and Epidemiology Research Group, American Cancer Society, 250 Williams St NW, Atlanta, GA, 30303, USA.
Stanley R HamiltonCity of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010, USA.
Sophia HarlidDepartment of Radiation Sciences, Oncology Unit, Umeå University, SE-901 87, Umeå, Sweden.ORCID http://orcid.org/0000-0001-8540-6891
Lawrence E HeislerOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Akihisa HidakaPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
John L HopperUniversity of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-4440-3368
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0001-6027-9806
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0002-8964-6160
Paul M KrzyzanowskiOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Mathieu LemireOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Xuemei LuoOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Elaine R MardisInstitute for Genomic Medicine, Nationwide Children's Hospital and The Ohio State University College of Medicine, 575 Children's Crossroad, Columbus, OH, 43215, USA.ORCID http://orcid.org/0000-0002-5892-1553
John D McPhersonOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.ORCID http://orcid.org/0000-0001-8049-9347
Jessica K MillerOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Victor MorenoOncology Data Analytics Program, Catalan Institute of Oncology and ONCOBELL Program, IDIBELL, Avinguda de la Granvia de l'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2818-5487
Xinmeng Jasmine MuDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Reiko NishiharaDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Nickolas PapadopoulosDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Institution, 1650 Orleans Street, Baltimore, MD, 21231, USA.
Danielle PasternackOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Michael J QuistPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Adilya RafikovaOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Emma E G ReidOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Eve ShinbrotHuman Genome Sequencing Centre, Baylor College of Medicine, One Baylor Plaza, Alkek N1419, Houston, TX, 77030, USA.
Brian H ShirtsDepartment of Laboratory Medicine, University of Washington, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-7188-6764
Lincoln D SteinOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Cherie D TeneyOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Lee TimmsOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Caroline Y UmBehavioral and Epidemiology Research Group, American Cancer Society, 250 Williams St NW, Atlanta, GA, 30303, USA.ORCID http://orcid.org/0000-0001-5449-6230
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, SE-901 87, Umeå, Sweden.ORCID http://orcid.org/0000-0002-9692-101X
Megan Van TasselOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Xiaolong WangPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
David A WheelerHuman Genome Sequencing Centre, Baylor College of Medicine, One Baylor Plaza, Alkek N1419, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-9056-6299
Christina K YungOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.ORCID http://orcid.org/0000-0003-2958-150X
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Shuji OginoBroad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA.
Andrea GsurInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschekagasse 8a, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-9795-1528
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0001-8786-0043
Steven GallingerOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, 250 Williams St NW, Atlanta, GA, 30303, USA.
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Wei SunPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
Thomas J HudsonOntario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA. upeters@fredhutch.org.ORCID http://orcid.org/0000-0001-5666-9318
Ontario Institute for Cancer Research · CAFred Hutch Cancer Center · USBroad Institute · USGerman Cancer Research Center · DEUniversity of Washington · USAmerican Cancer Society · USThe University of Melbourne · AUBaylor College of Medicine · USHarvard University · USMayo Clinic · USMedical University of Vienna · ATNational Institutes of Health · USUmeå University · SEUniversity of Southern California · USBrigham and Women's Hospital · USCedars-Sinai Medical Center · USCity of Hope · USEmory University · USInstitut d'Investigació Biomédica de Bellvitge · ESNationwide Children's Hospital · US
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MThe Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0MThe Colon Cancer Family Registry: OntarioU24CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 2008 to 2011
$4.1MMolecular Correlates of Outcomes in Clinical Trials of Colon CancerR01CA176272 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHAN, ANDREW T, NEWCOMB, POLLY A · 2013 to 2017
$2.5MHormones and Colon Cancer: Epigenetic Subtypes, Risk, and SurvivalR01CA076366 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1998 to 2009
$2.4MCIHRNCI NIH HHS P30 CA015704NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA176272NCI NIH HHS R01 CA223498NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA206110NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS UM1 CA186107
Abstract
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge of CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional genes significantly mutated in CRC. We find that among hypermutated tumors, an increased mutation burden is associated with improved CRC-specific survival (HR = 0.42, 95% CI: 0.21-0.82). Mutations in TP53 are associated with poorer CRC-specific survival, which is most pronounced in cases carrying TP53 mutations with predicted 0% transcriptional activity (HR = 1.53, 95% CI: 1.21-1.94). Furthermore, we observe differences in mutational frequency of several genes and pathways by tumor location, stage, and sex. Overall, this large study provides deep insights into somatic mutations in CRC, and their potential relationships with survival and tumor features.
Indexed as
Colonic NeoplasmsColorectal NeoplasmsHigh-Throughput Nucleotide SequencingHumansINDEL MutationMutationNeoplasm ProteinsPrognosisTumor Suppressor Protein p53Neoplasm ProteinsTumor Suppressor Protein p53
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