Evidence map›Paper›PMID 32686662›Full record

ArticleCell death & disease2020

Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells.

ZhaoMin Lin, ZhaoYang Wang, XueWen Zhou, Ming Zhang, DongFang Gao, Lu Zhang, Peng Wang, Yuan Chen, YuXing Lin, BaoXiang Zhao and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

ZhaoMin LinInstitute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China.
ZhaoYang WangShandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, PR China.
XueWen ZhouInstitute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, PR China.
Ming ZhangInstitute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China.
DongFang GaoInstitute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China.
Lu ZhangInstitute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China.
Peng WangInstitute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China.
Yuan ChenInstitute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China.
YuXing LinInstitute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China.
BaoXiang ZhaoInstitute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, PR China.
JunYing MiaoShandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, PR China.
Feng KongInstitute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China. kongfeng@sdu.edu.cn.
Second Hospital of Shandong University · CNShandong University · CNShanghai Institute of Organic Chemistry · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of fluorescent thiazole-pyrazoline derivatives was synthesized and their structures were characterized by

Indexed as

A549 CellsAnimalsAutophagyCell Line, TumorCell ProliferationCell SurvivalChick EmbryoFluorescenceFluorouracilHumansInhibitory Concentration 50Lung NeoplasmsLysosomesPyrazolesStructure-Activity RelationshipTacrolimus Binding Protein 1AFluorouracilPyrazolesTacrolimus Binding Protein 1AThiazolesTOR Serine-Threonine Kinases

Identifiers

PMID32686662
PMCPMC7371735
OpenAlexW3042477942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.