Evidence map›Paper›PMID 32686659›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2020

Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway.

Qibing Niu, Wanli Sun, Quan Chen, Yang Long, Wanjun Cao, Shiqi Wen, Anqiang Li, Fang Dong, Hao Shi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Neurochemical research · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Qibing NiuDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Wanli SunDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Quan ChenDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Yang LongDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Wanjun CaoDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Shiqi WenDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Anqiang LiDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Fang DongDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Hao ShiDepartment of Vascular Surgery, People's Hospital in Gansu Province, Gansu University of Chinese Medicine, Lanzhou, Gansu, China (mainland).
Gansu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Ischemia/reperfusion (I/R) injury not only exists in ischemic tissues and organs, but also can cause damage to distant tissues and organs. As the largest metabolic organ of the human body, the liver is very vulnerable to injury after limb I/R. However, the mechanism of liver injury caused by limb I/R injury has not been fully elucidated. This study investigated the effect and mechanism of ischemic postconditioning (IPO) on the liver after hindlimb I/R in rats. MATERIAL AND METHODS A rat model of hindlimb I/R was established and treated by IPO. Liver function, changes of oxidative stress index and inflammation, Bcl-2 and Bax proteins, and apoptosis were assessed. The structural changes were observed by electron microscopy. GSK-3ß/Fyn/Nrf2 levels were detected by quantitative PCR and Western blot. RESULTS IPO significantly reduced serum AST, ALP, LDH, and ALT levels induced by I/R. Compared with the I/R group, the levels of SOD, GSH-Px, and CAT in the IPO group were significantly increased, while the levels of MDA, MPO, and ROS were significantly decreased. The IPO group had significantly higher Bcl-2 level and significantly lower Bax level compared to the I/R group. Consistently, IPO decreased the apoptosis rate induced by I/R. Furthermore, IPO lowered the levels of TNF-alpha, IL-1ß, IL-10, and INF-γ and alleviated the ultrastructural changes of hepatocytes. Finally, Nrf2, Fyn, and GSK-3ß mRNA and protein levels in the IPO group were significantly higher than in the I/R group. CONCLUSIONS IPO protects against liver injury caused by I/R injury of the hindlimb, possibly via the GSK-3ß/Fyn/Nrf2 pathway.

Indexed as

AnimalsApoptosisbcl-2-Associated X ProteinGlycogen Synthase Kinase 3 betaHepatocytesIschemiaIschemic PostconditioningLiverMaleNF-E2-Related Factor 2Oxidative StressProto-Oncogene Proteins c-fynRatsRats, Sprague-DawleyReperfusionReperfusion Injurybcl-2-Associated X ProteinGlycogen Synthase Kinase 3 betaNfe2l2 protein, ratNF-E2-Related Factor 2Proto-Oncogene Proteins c-fynTumor Necrosis Factor-alpha

Identifiers

PMID32686659
PMCPMC7392060
OpenAlexW3044512868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.