Evidence map›Paper›PMID 32686646›Full record

ArticleeLife2020

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors.

Maria M Mikedis, Yuting Fan, Peter K Nicholls, Tsutomu Endo, Emily K Jackson, Sarah A Cobb, Dirk G de Rooij, David C Page

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  17. Cells · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Maria M MikedisWhitehead Institute, Cambridge, United States.ORCID 0000-0001-7800-7120
Yuting FanWhitehead Institute, Cambridge, United States.ORCID 0000-0002-2143-0187
Peter K NichollsWhitehead Institute, Cambridge, United States.ORCID 0000-0002-5540-442X
Tsutomu EndoWhitehead Institute, Cambridge, United States.ORCID 0000-0001-9394-362X
Emily K JacksonWhitehead Institute, Cambridge, United States.ORCID 0000-0002-2972-4139
Sarah A CobbWhitehead Institute, Cambridge, United States.
Dirk G de RooijWhitehead Institute, Cambridge, United States.ORCID 0000-0003-3932-4419
David C PageWhitehead Institute, Cambridge, United States.ORCID 0000-0001-9920-3411
Whitehead Institute for Biomedical Research · USHoward Hughes Medical Institute · USSun Yat-sen University · CN

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Regulation of the cell cycle during meiotic prophase I by MEIOCF32HD093391 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI MIKEDIS, MARIA · 2017 to 2019
$151k
Hope Funds for Cancer Research HFCR-15-06-06Howard Hughes Medical InstituteNational Health and Medical Research Council GNT1053776National Key Research and Development Program of China 2017YFC1001600National Natural Science Foundation of China 81471507NICHD NIH HHS F32 HD093391NIGMS NIH HHS T32 GM007287
6 · The paper itself

Abstract

Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with chemical synchronization of spermatogenesis. We find that the absence of

Indexed as

Cell DifferentiationRNA-Binding ProteinsSpermatogenesis3' Untranslated RegionsAnimalsMaleMiceSpermatogonia3' Untranslated RegionsDAZL protein, mouseRNA-Binding ProteinsDazldevelopmental biologymousespermatogenesistranslation

Identifiers

PMID32686646
PMCPMC7445011
OpenAlexW3045237925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.