ArticleAmerican journal of physiology. Renal physiology2020
IL-10 treatment decreases blood pressure in male, but not female, spontaneously hypertensive rats.
Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Identifying pathways to cardiovascular mortality by causal graphical models and mediation analysis among hypertensive patients: insights from a prospective study.Journal of translational medicine · 2025Article
- Immune mechanisms in the pathophysiology of hypertension.Nature reviews. Nephrology · 2024Review
- Modulation of TNF-α, interleukin-6, and interleukin-10 by nebivolol-valsartan and nebivolol-lisinopril polytherapy in SHR rats.Pharmacology research & perspectives · 2024Article
- Endothelial mechanical stretch regulates the immunological synapse interface of renal endothelial cells in a sex-dependent manner.American journal of physiology. Renal physiology · 2023Article
- Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension.American journal of physiology. Renal physiology · 2022Article
- Sex differences in apoptosis do not contribute to sex differences in blood pressure or renal T cells in spontaneously hypertensive rats.Frontiers in physiology · 2022Article
- Inflammation and immunity connect hypertension with adverse COVID-19 outcomes.Frontiers in genetics · 2022Article
- Evaluation of Potential Herb-Drug Interactions Between Shengmai Injection and Losartan Potassium in Rat andFrontiers in pharmacology · 2022Article
- Article
- The moderation effect of remnant cholesterol for linking cerebrospinal fluid interleukin 10 to blood pressure.Science progressArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that induces nitric oxide (NO) production. IL-10 supplementation has been previously shown to lower blood pressure (BP) in male hypertensive mice, but the effect of exogenous IL-10 in hypertensive female rodents has not been studied. For the present study, we hypothesized that chronic infusion of IL-10 in hypertensive rats would lower BP concomitant with an increase in renal NO synthase (NOS) activity. Male and female spontaneously hypertensive rats (SHRs; 12 wk old) were randomized to receive IL-10 infusion by subcutaneous minipump (3.5 µg·kg
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