Evidence map›Paper›PMID 32686475›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2020

Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype.

Akshaya Chandrasekaran, May Y Lee, Xuexin Zhang, Shaheen Hasan, Habben Desta, Scott A Tenenbaum, J Andrés Melendez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Mechanisms of aging, age-associated diseases, and lifespan determination.Experimental biology and medicine (Maywood, N.J.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Akshaya ChandrasekaranSUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, Albany, NY 12203, USA.
May Y LeeSUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, Albany, NY 12203, USA.ORCID 0000-0002-3432-4279
Xuexin ZhangCollege of Medicine, Penn State University, Hershey, PA 17033, USA.
Shaheen HasanSUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, Albany, NY 12203, USA.
Habben DestaSUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, Albany, NY 12203, USA.
Scott A TenenbaumSUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, Albany, NY 12203, USA.
J Andrés MelendezSUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, Albany, NY 12203, USA.ORCID 0000-0001-8021-3097
SUNY Polytechnic Institute · USPenn State Milton S. Hershey Medical Center · US

Funding

Development of a Structurally Interacting RNA (sxRNA) technologyR01GM125870 · NIGMS · SUNY POLYTECHNIC INSTITUTE · PI TENENBAUM, SCOTT A · 2018 to 2021
$2.6M
NIGMS NIH HHS R01 GM125870
6 · The paper itself

Abstract

impact statementThrough its ability to evoke responses from cells in a paracrine fashion, the senescence-associated secretory phenotype (SASP) has been linked to numerous age-associated disease pathologies including tumor invasion, cardiovascular dysfunction, neuroinflammation, osteoarthritis, and renal disease. Strategies which limit the amplitude and duration of SASP serve to delay age-related degenerative decline. Here we demonstrate that the SASP regulation is linked to shifts in intracellular Ca

Indexed as

Cellular SenescenceCalciumCalcium SignalingCatalaseCell LineHomeostasisHumansHydrogen PeroxideImidazolesOxidation-ReductionTOR Serine-Threonine KinasesTRPC6 Cation Channel1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazoleCalciumCatalaseHydrogen PeroxideImidazolesTOR Serine-Threonine KinasesTRPC6 Cation ChannelTRPC6 protein, humancalciumhydrogen peroxidemTORSASPSenescenceTRPC6

Identifiers

PMID32686475
PMCPMC7787549
OpenAlexW3044619203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.