ArticleJournal of neuroscience research2020
Impact of network-targeted multichannel transcranial direct current stimulation on intrinsic and network-to-network functional connectivity.
Article in Journal of neuroscience research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The efficacy and safety of transcranial direct current stimulation in patients with ADHD: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Transcutaneous and transcranial electrical stimulation for enhancing military performance: an update and systematic review.Frontiers in human neuroscience · 2025Pooled it
- Neural correlates of N-back task performance and proposal for corresponding neuromodulation targets in psychiatric and neurodevelopmental disorders.Psychiatry and clinical neurosciences · 2022Pooled it
- Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS.Scientific reports · 2022Trial
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Effect of acupuncture on brain activity in patients with decreasing ovarian reserve: a resting-state functional magnetic resonance imaging study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study.Scientific reports · 2024Article
- Study Protocol for a Randomized Controlled Trial: Evaluating the Impact of Acupuncture on Menstrual Regulation and Pregnancy Enhancement in Patients with DOR Using Rs-fMRI to Assess Brain Functional Networks.Journal of multidisciplinary healthcare · 2024Article
- Network-based transcranial direct current stimulation enhances attention function in healthy young adults: a preliminary study.Frontiers in human neuroscience · 2024Article
- Transcranial electrical stimulation during functional magnetic resonance imaging in patients with genetic generalized epilepsy: a pilot and feasibility study.Frontiers in neuroscience · 2024Article
- Non-invasive brain stimulation in cognitive sciences and Alzheimer's disease.Frontiers in human neuroscience · 2024Review
- Article
- Individual response to transcranial direct current stimulation as a function of working memory capacity and electrode montage.Frontiers in human neuroscience · 2023Article
- Toward noninvasive brain stimulation 2.0 in Alzheimer's disease.Ageing research reviews · 2022Review
- Neuromodulation for Chronic Daily Headache.Current pain and headache reports · 2022Review
- Current State of Potential Mechanisms Supporting Low Intensity Focused Ultrasound for Neuromodulation.Frontiers in human neuroscience · 2022Review
- Network-Based Transcranial Direct Current Stimulation May Modulate Gait Variability in Young Healthy Adults.Frontiers in human neuroscience · 2022Article
- Patient-Tailored, Home-Based Non-invasive Brain Stimulation for Memory Deficits in Dementia Due to Alzheimer's Disease.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Dynamics within and between functional resting-state networks have a crucial role in determining both healthy and pathological brain functioning in humans. The possibility to noninvasively interact and selectively modulate the activity of networks would open to relevant applications in neuroscience. Here we tested a novel approach for multichannel, network-targeted transcranial direct current stimulation (net-tDCS), optimized to increase excitability of the sensorimotor network (SMN) while inducing cathodal inhibitory modulation over prefrontal and parietal brain regions negatively correlated with the SMN. Using an MRI-compatible multichannel transcranial electrical stimulation (tES) device, 20 healthy participants underwent real and sham tDCS while at rest in the MRI scanner. Changes in functional connectivity (FC) during and after stimulation were evaluated, looking at the intrinsic FC of the SMN and the strength of the negative connectivity between SMN and the rest of the brain. Standard, bifocal tDCS targeting left motor cortex (electrode ~C3) and right frontopolar (~Fp2) regions was tested as a control condition in a separate sample of healthy subjects to investigate network specificity of multichannel stimulation effects. Net-tDCS induced greater FC increase over the SMN compared to bifocal tDCS, during and after stimulation. Moreover, exploratory analysis of the impact of net-tDCS on negatively correlated networks showed an increase in the negative connectivity between SMN and prefrontal/parietal areas targeted by cathodal stimulation both during and after real net-tDCS. Results suggest preliminary evidence of the possibility of manipulating distributed network connectivity patterns through net-tDCS, with potential relevance for the development of cognitive enhancement and therapeutic tES solutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.