Observational studyActa paediatrica (Oslo, Norway : 1992)2021
Multicentre study found that adherence to national antibiotic recommendations for neonatal early-onset sepsis was low.
Observational study in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05274776 (Safely Reduce Newborn Antibiotic Exposure With the Early-onset Sepsis Calculator), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safely Reduce Newborn Antibiotic Exposure With the Early-onset Sepsis Calculator: a Cluster Randomized Study (EOS Calculator RCT)
Who cites it
15 citing papers in PubMed.
- Real-world use of Serial Clinical Observation in culture-proven early-onset sepsis: timing of recognition, treatment and retrospective comparison with the Neonatal Sepsis Calculator.European journal of pediatrics · 2026Observational
- Article
- Safety and effectiveness of the early-onset sepsis calculator to reduce antibiotic exposure in at-risk newborns: a cluster-randomised controlled trial.EClinicalMedicine · 2025Article
- Impact of NICE clinical guidelines for prevention and treatment of neonatal infections on antibiotic use in very preterm infants in England and Wales: an interrupted time series analysis.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Incidence of Antibiotic Exposure for Suspected and Proven Neonatal Early-Onset Sepsis between 2019 and 2021: A Retrospective, Multicentre Study.Antibiotics (Basel, Switzerland) · 2024Article
- Factors Associated with Prolonged Antibiotic Therapy in Neonates with Suspected Early-Onset Sepsis.Antibiotics (Basel, Switzerland) · 2024Article
- Adherence to Dutch Guideline in Hospitalized Anorexia Nervosa Adolescents.Global pediatric health · 2024Article
- Blood culture versus antibiotic use for neonatal inpatients in 61 hospitals implementing with the NEST360 Alliance in Kenya, Malawi, Nigeria, and Tanzania: a cross-sectional study.BMC pediatrics · 2023Article
- Barriers and Facilitators to the Implementation of the Early-Onset Sepsis Calculator: A Multicenter Survey Study.Children (Basel, Switzerland) · 2023Article
- Group BAntibiotics (Basel, Switzerland) · 2023Review
- Article
- Current treatment practice of functional abdominal pain disorders in children: A multicenter survey.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Article
- Multicentre study found that adherence to national antibiotic recommendations for neonatal early-onset sepsis was low.Acta paediatrica (Oslo, Norway : 1992) · 2021Observational
- Umbilical Cord Procalcitonin to Detect Early-Onset Sepsis in Newborns: A Promising Biomarker.Frontiers in pediatrics · 2021Article
- Neonatal early-onset sepsis calculator recommended significantly less empiric antibiotic treatment than national guidelines.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOur aim was to evaluate adherence to the Dutch neonatal early-onset sepsis (EOS) guidelines, adapted from UK guidance. We also looked at the effect on antibiotic recommendations and duration.
methodThis was a multicentre, prospective observational cross-sectional study carried out in seven hospitals in the Netherlands between 1 September 2018 and 1 November 2019. We enrolled 1024 neonates born at 32 weeks of gestation or later if they demonstrated at least one EOS risk factor or clinical signs of infection.
resultsThe Dutch guidelines recommended antibiotic treatment for 438/1024 (42.8%) of the neonates designated at risk, but only 186/438 (42.5%) received antibiotics. The guidelines advised withholding antibiotics for 586/1024 (57.2%) of neonates and in 570/586 (97.3%) cases the clinicians adhered to this recommendation. Blood cultures were obtained for 182/186 (97.8%) infants who started antibiotics and only four were positive, for group B streptococci. Antibiotic treatment was continued for more than 3 days in 56/178 (31.5%) neonates, despite a negative blood culture.
conclusionLow adherence to the Dutch guidelines meant that the majority of neonates did not receive the antibiotic treatment that was recommended, while some antibiotic use was prolonged despite negative blood cultures. The guidelines need to be revised.
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