ArticleCell reports. Physical science2020
Cellular Contact Guidance Emerges from Gap Avoidance.
Article in Cell reports. Physical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
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Who cites it
26 citing papers in PubMed.
- Plasma Treatment Enhances Cytocompatibility on Patterned Perfluoroethylene Propylene.Journal of functional biomaterials · 2026Article
- Feedback-Driven Dynamical Model for Axonal Extension on Parallel Micropatterns.Biomimetics (Basel, Switzerland) · 2025Article
- Light-Responsive Liquid Crystal Surface Topographies for Dynamic Stimulation of Cells.ACS applied materials & interfaces · 2025Article
- Fabrication of Multiscale, Multidirectional Orientated Collagen Hydrogels with Guided Cell Alignment Using Fluidics and a Three-Dimensional Printing.ACS biomaterials science & engineering · 2025Article
- A multimodal microfluidic-based platform integrating topographical and equibiaxial mechanical cues for next-generationFrontiers in bioengineering and biotechnology · 2025Article
- Spatial regulation of substrate adhesion directs fibroblast morphotype and phenotype.PNAS nexus · 2024Article
- Dimensionality Matters: Exploiting UV-Photopatterned 2D and Two-Photon-Printed 2.5D Contact Guidance Cues to Control Corneal Fibroblast Behavior and Collagen Deposition.Bioengineering (Basel, Switzerland) · 2024Article
- Hs27 fibroblast response to contact guidance cues.Scientific reports · 2023Article
- Shape-Morphing Photoresponsive Hydrogels Reveal Dynamic Topographical Conditioning of Fibroblasts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Biased Random Walk Model of Neuronal Dynamics on Substrates with Periodic Geometrical Patterns.Biomimetics (Basel, Switzerland) · 2023Article
- Contact Guidance Drives Upward Cellular Migration at the Mesoscopic Scale.Cellular and molecular bioengineering · 2023Article
- Contact Guidance of Connective Tissue Fibroblasts on Submicrometer Anisotropic Topographical Cues Is Dependent on Tissue of Origin, β1 Integrins, and Tensin-1 Recruitment.ACS applied materials & interfaces · 2023Article
- Printing channels with millimeter-scale curvature and deciphering their effect on the proliferation, morphology, orientation, and migration of M-22 cells.International journal of bioprinting · 2023Article
- Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts.APL bioengineering · 2022Article
- The influence of entropic crowding in cell monolayers.Biophysical journal · 2022Article
- Cell reorientation on a cyclically strained substrate.PNAS nexus · 2022Article
- Wool Keratin Nanoparticle-Based Micropatterns for Cellular Guidance Applications.ACS applied nano materials · 2022Article
- Combined Traction Force-Atomic Force Microscopy Measurements of Neuronal Cells.Biomimetics (Basel, Switzerland) · 2022Article
- 3D Interfacial and Spatiotemporal Regulation of Human Neuroepithelial Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Contact guidance as a consequence of coupled morphological evolution and motility of adherent cells.Biomechanics and modeling in mechanobiology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the presence of anisotropic biochemical or topographical patterns, cells tend to align in the direction of these cues-a widely reported phenomenon known as "contact guidance." To investigate the origins of contact guidance, here, we created substrates micropatterned with parallel lines of fibronectin with dimensions spanning multiple orders of magnitude. Quantitative morphometric analysis of our experimental data reveals two regimes of contact guidance governed by the length scale of the cues that cannot be explained by enforced alignment of focal adhesions. Adopting computational simulations of cell remodeling on inhomogeneous substrates based on a statistical mechanics framework for living cells, we show that contact guidance emerges from anisotropic cell shape fluctuation and "gap avoidance," i.e., the energetic penalty of cell adhesions on non-adhesive gaps. Our findings therefore point to general biophysical mechanisms underlying cellular contact guidance, without the necessity of invoking specific molecular pathways.
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Registered trials
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