ArticleResearch and practice in thrombosis and haemostasis2020
Determination of von Willebrand factor level in patient with sickle cell diseasein vaso-occlusive crisis.
Article in Research and practice in thrombosis and haemostasis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- Genomics-driven drug repurposing and novel targets identification for sickle cell disease in Saudi patients.Frontiers in bioinformatics · 2025Article
- Contribution of ADAMTS13-independent VWF regulation in sickle cell disease.Journal of thrombosis and haemostasis : JTH · 2022Article
- Determination of von Willebrand factor level in patient with sickle cell diseasein vaso-occlusive crisis.Research and practice in thrombosis and haemostasis · 2020Article
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3 authors at 3 institutions in 1 country.
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Abstract
backgroundSickle cell anemia (SCA) is a hypercoagulable state characterized by a significant alteration in hemostatic parameters that may predispose to increased risk of vaso-occlusive crisis (VOC). The role of von Willebrand factor (VWF) in the pathogenesis of VOC has not been fully investigated in Nigeria.
objectiveThe objective of this study was to evaluate the level of VWF in subjects with sickle cell disease (SCD) in Calabar, Nigeria, to determine its role in the pathogenesis of VOC.
methodsThis was a comparative study carried out at the University of Calabar Teaching Hospital, Calabar, Nigeria. Sixty patients with SCA in VOC and 50 healthy controls were included. VWF levels were measured using Assaypro enzyme-linked immunosorbent assay kits.
resultsThe mean age of patients with SCA in VOC and controls was 23.5 ± 7.2 years and 26.5 ± 5.6 years, respectively. The means (standard deviations) of VWF in patients in VOC and controls were 2.52 ± 0.34 IU/mL and 1.41 ± 0.23 IU/mL, respectively. There was no correlation of hematocrit and VWF in VOC (
conclusionsLevels of VWFare elevated in a VOC state and thus may be implicated in the pathogenesis of VOC.
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