Evidence map›Paper›PMID 32685741›Full record

ArticleHeliyon2020

Detection of somatic

Hiroshi Yokouchi, Hiroshi Nishihara, Toshiyuki Harada, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie and 12 more

Abstract read
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Liquid Biopsy-Based Profiling ofInternational journal of hepatology · 2026
    Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Hiroshi YokouchiDepartment of Pulmonary Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Hiroshi NishiharaDepartment of Translational Pathology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
Toshiyuki HaradaCenter for Respiratory Diseases, JCHO Hokkaido Hospital, Sapporo 062-8618, Japan.
Shigeo YamazakiDepartment of Thoracic Surgery, Keiyukai Sapporo Hospital, Sapporo 003-0027, Japan.
Hajime KikuchiFirst Department of Medicine, Hokkaido University School of Medicine, Sapporo 060-8638, Japan.
Satoshi OizumiDepartment of Respiratory Medicine, National Hospital Organization Hokkaido Cancer Center, Sapporo 003-0804, Japan.
Hidetaka UramotoSecond Department of Surgery, University of Occupational and Environmental Health, Kita-kyushu 807-8555, Japan.
Fumihiro TanakaSecond Department of Surgery, University of Occupational and Environmental Health, Kita-kyushu 807-8555, Japan.
Masao HaradaDepartment of Respiratory Medicine, National Hospital Organization Hokkaido Cancer Center, Sapporo 003-0804, Japan.
Kenji AkieDepartment of Respiratory Disease, Sapporo City General Hospital, Sapporo 060-8604, Japan.
Fumiko SugayaDepartment of Respiratory Medicine, Teine Keijinkai Hospital, Sapporo 006-8555, Japan.
Yuka FujitaDepartment of Respiratory Medicine, National Hospital Organization Asahikawa Medical Center, Asahikawa 070-8644, Japan.
Kei TakamuraFirst Department of Medicine, Obihiro Kosei Hospital, Obihiro 080-0016, Japan.
Tetsuya KojimaDepartment of Medical Oncology, KKR Sapporo Medical Center, Sapporo 062-0931, Japan.
Mitsunori HiguchiDepartment of Thoracic Surgery, Fukushima Red Cross Hospital, Fukushima 960-8530, Japan.
Osamu HonjoDepartment of Respiratory Medicine, Sapporo-Kosei General Hospital, Sapporo 060-0033, Japan.
Yoshinori MinamiRespiratory Center, Asahikawa Medical University, Asahikawa 078-8510, Japan.
Naomi WatanabeDepartment of Internal Medicine, Sunagawa City Medical Center, Sunagawa 073-0196, Japan.
Masaharu NishimuraFirst Department of Medicine, Hokkaido University School of Medicine, Sapporo 060-8638, Japan.
Hiroyuki SuzukiDepartment of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Hirotoshi Dosaka-AkitaDepartment of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
Hiroshi IsobeDepartment of Medical Oncology, KKR Sapporo Medical Center, Sapporo 062-0931, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesFew reports have explored clinical biomarkers, including those identified by targeted exome sequencing (TES) of surgically resected small-cell lung cancer (SCLC) and correlation with patient survival. PATIENTS AND

methodsWe collected formalin-fixed paraffin-embedded tumor samples from 127 patients with SCLC who had undergone surgery and analysed nonsynonymous somatic gene mutation profiles by TES of 26 cancer-related genes using next-generation sequencing (NGS) and web databases (UMIN Registration No. 000010117).

resultsWe detected 38 nonsynonymous somatic

conclusionThese data suggested that TES may play a critical role for promoting reverse-translational studies, including investigations of the biology of

Indexed as

BioinformaticsCancer researchClinical geneticsClinical researchGeneticsMutationNext-generation sequencingOncologyRespiratory systemSmall-cell lung cancerSurgeryTP53

Identifiers

PMID32685741
PMCPMC7358392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.