ArticleLearning health systems2020
Learning health care systems: Highly needed but challenging.
Article in Learning health systems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Blueprint for clinical N-of-1 strategies with off-label precision treatments in monogenic epilepsies.Orphanet journal of rare diseases · 2025Review
- Transforming the future of health: building learning health systems across the globe.Health affairs scholar · 2025Article
- Towards a shared understanding of the learning health system in a large academic-based health system: A qualitative analysis.Health services management research · 2025Article
- Using artificial intelligence and predictive modelling to enable learning healthcare systems (LHS) for pandemic preparedness.Computational and structural biotechnology journal · 2024Review
- Which heart failure patients benefit most from non-invasive telemedicine? An overview of current evidence and future directions.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024Review
- Comparison of the Response to an Electronic Versus a Traditional Informed Consent Procedure in Terms of Clinical Patient Characteristics: Observational Study.Journal of medical Internet research · 2024Observational
- An ethics framework for the transition to an operational learning healthcare system.Learning health systems · 2024Article
- Randomised trials conducted using cohorts: a scoping review.BMJ open · 2024Article
- Building a Sustainable Learning Health Care System for Pregnant and Lactating People: Interview Study Among Data Access Providers.JMIR pediatrics and parenting · 2024Article
- Learning healthcare systems in cardiology: A qualitative interview study on ethical dilemmas of a learning healthcare system.Learning health systems · 2024Article
- Stimulating solidarity to improve knowledge on medications used during pregnancy : A contribution from the ConcePTION project.BMC medical ethics · 2023Article
- Attitudes of primary healthcare chief physicians towards research in Finland - a national study.Scandinavian journal of primary health care · 2023Article
- Article
- Optimizing cardiovascular risk assessment and registration in a developing cardiovascular learning health care system: Women benefit most.PLOS digital health · 2023Article
- Setting up a Governance Framework for Secondary Use of Routine Health Data in Nursing Homes: Development Study Using Qualitative Interviews.Journal of medical Internet research · 2023Article
- Personalized medicine in a community health system: the NorthShore experience.Frontiers in genetics · 2023Article
- Prioritizing Measures That Matter Within a Person-Centered Oncology Learning Health System.JNCI cancer spectrum · 2022Article
- A Learning Healthcare System for pregnant and breastfeeding women: what do women during preconception, pregnancy, and nursing think? - A qualitative study : A contribution from the ConcePTION project.BMC pregnancy and childbirth · 2022Article
- Motives for withdrawal of participation in biobanking and participants' willingness to allow linkages of their data.European journal of human genetics : EJHG · 2022Article
- Pursuing Public Health Benefit Within National Genomic Initiatives: Learning From Different Policies.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLearning health care systems (LHSs) have the potential to transform health care. However, this transformation process faces significant challenges. MATERIALS AND
methodsBased on proposals and early examples of LHSs in the literature and conceptual analysis of the LHS mission, we provide four models with distinct organizational and ethical implications that may facilitate the transformation.
resultsAn LHS could be developed in the following ways: by taking away practical impediments that prevent patients and professionals from engaging in scientific research (model 1: optimization LHS); by routinely analyzing observational data from electronic health records and other sources (model 2: comprehensive data LHS); by making clinical decisions based on the outcomes of the aforementioned data analyses and directly evaluating the outcomes in order to continuously improve decision-making (model 3: real-time LHS); or by embedding clinical trials into routine care delivery (model 4: full LHS).
conclusionsEach model has different ethical implications for consent and oversight. Also, the four-model approach shows that reorganizing a health care center into an LHS is not an all-or-nothing decision. Rather, it is a choice from a menu of possibilities. Instead of discussing the advantages and disadvantages of the LHS menu in its entirety, the medical community should focus on the designs and ethical aspects of each of the separate options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.