ArticleAlzheimer's & dementia (New York, N. Y.)2020
Shared mechanisms for cognitive impairment and physical frailty: A model for complex systems.
Article in Alzheimer's & dementia (New York, N. Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prediction model for cognitive frailty in older adults: A systematic review and critical appraisal.Frontiers in aging neuroscience · 2023Pooled it
- Cognitive impairment in people with physical frailty using the phenotype model: A systematic review and meta analysis.International journal of geriatric psychiatry · 2022Pooled it
- Mild cognitive impairment has a direct effect on gait speed even when accounting for frailty.BMC geriatrics · 2026Article
- Association of inflammatory biomarkers with physical and cognitive frailty in a Spanish population of older adults.GeroScience · 2026Article
- Evolution and interrelation of physical frailty and mild cognitive impairment up to two years after kidney transplantation: a multi-center prospective cohort study.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Association of the HALP score with baseline and incident physical-cognitive comorbidity and mortality: evidence from the WCHAT and UK Biobank cohorts.Frontiers in public health · 2026Article
- Impact of physical exercise on memory and learning in healthy older women: a quasi-experimental study.BMC geriatrics · 2025Article
- Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort.GeroScience · 2025Article
- Cognitive, Neuropsychological and Biological Effects of Oxygen-Ozone Therapy on Frailty: A Study Protocol for a 5-Week, Randomized, Placebo-Controlled Trial.Journal of personalized medicine · 2024Article
- Charting Alzheimer's Disease and Dementia: Epidemiological Insights, Risk Factors and Prevention Pathways.Journal of clinical medicine · 2024Review
- Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment.Aging and disease · 2024Review
- Moving towards the detection of frailty with biomarkers: A population health study.Aging cell · 2024Article
- Development and validation of prediction model for older adults with cognitive frailty.Aging clinical and experimental research · 2024Article
- Review
- Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women.Journal of cachexia, sarcopenia and muscle · 2023Article
- Cognitive and physical impairment in spinal cord injury: A scoping review and call for new understanding.The journal of spinal cord medicine · 2023Article
- The concurrent impact of mild cognitive impairment and frailty syndrome in heart failure.Archives of medical science : AMS · 2023Article
- Editorial: World Alzheimer's month: cognitive frailty, Alzheimer's disease and dementia: how do they relate? The role of cognitive reserve.Frontiers in psychology · 2023Article
- Article
- Exercise interventions for older people with cognitive frailty-a scoping review.BMC geriatrics · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe describe findings from a large study that provide empirical support for the emerging construct of cognitive frailty and put forth a theoretical framework that may advance the future study of complex aging conditions. While cognitive impairment and physical frailty have long been studied as separate constructs, recent studies suggest they share common etiologies. We aimed to create a population predictive model to gain an understanding of the underlying biological mechanisms for the relationship between physical frailty and cognitive impairment.
methodsData were obtained from the longitudinal "
resultsWe developed two highly accurate predictive models, with a Model I area under the curve (AUC) of 0.88 (95% confidence interval [CI] 0.83-0.90) and a Model II AUC of 0.86 (95% CI 0.80-0.90). These models indicate cognitive frailty is driven by dysregulation across multiple cellular processes including genetic alterations, nutrient and lipid metabolism, and elevated levels of circulating pro-inflammatory proteins. DISCUSSION: While our results establish a foundation for understanding the underlying biological mechanisms for the relationship between cognitive decline and physical frailty, further examination of the molecular pathways associated with our predictive biomarkers is warranted. Our framework is in alignment with other proposed biological underpinnings of Alzheimer's disease such as genetic alterations, immune system dysfunction, and neuroinflammation.
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