SynthesisJournal of diabetes research2020
Heritability and Genetics of Type 2 Diabetes Mellitus in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.
Synthesis in Journal of diabetes research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Randomised controlled trials on prevention, diagnosis and treatment of diabetes in African countries: a systematic review.BMJ open · 2022Pooled it
- Analysis of Whole Exome Sequencing Results of Type 2 Diabetic Pedigree.Molecular genetics & genomic medicine · 2026Article
- Expression of APOL1 and NOTCH2 genes in patients with type 2 diabetes mellitus attending babcock University Teaching Hospital, Ogun State, Nigeria.Scientific reports · 2026Article
- The development of type 2 diabetes amongst sibling pairs in the South-South region of Nigeria: The effect of genetics, environment and lifestyle.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Genetics and Genomics in Sickle Cell Disease in Africa.American journal of hematology · 2026Review
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- African regional and national burden of diabetes mellitus and its attributable risk factors from 1990 to 2021: results from the global burden of disease study 2021.Frontiers in endocrinology · 2025Article
- The economic burden of type 2 diabetes on the public healthcare system in Kenya: a cost of illness study.BMC health services research · 2024Article
- Type 2 Diabetes Mellitus in Tanzania. A Narrative Review of Epidemiology and Disease Trend.Current diabetes reviews · 2024Review
- Interactions between sex and the age at disease onset on cardiometabolic risk factors in a Ghanaian population with type 2 diabetes mellitus: A cross-sectional study.Health science reports · 2023Article
- Article
- Type 2 diabetes mellitus in sub-Saharan Africa: challenges and opportunities.Nature reviews. Endocrinology · 2022Review
- Associations of ATP-Sensitive Potassium Channel's Gene Polymorphisms With Type 2 Diabetes and Related Cardiovascular Phenotypes.Frontiers in cardiovascular medicine · 2022Article
- Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK.Diabetologia · 2022Article
- Lifestyle, Demographic and Clinical Correlates of Type 2 Diabetes Mellitus Among Urban and Rural Adults: A Community-Based Cross-Sectional Study.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSub-Saharan Africa (SSA) is observing an accelerating prevalence rate of type 2 diabetes mellitus (T2DM) influenced by gene-environment interaction of modifiable and nonmodifiable factors. We conducted a systematic review and meta-analysis on the heritability and genetic risk of T2DM in SSA.
methodsWe reviewed all published articles on T2DM in SSA between January 2000 and December 2019 and available in PubMed, Scopus, and Web of Science. Studies that reported on the genetics and/or heritability of T2DM or indicators of glycaemia were included. Data extracted included the study design, records of family history, pattern and characteristics of inheritance, genetic determinants, and effects estimates.
resultsThe pattern and characteristics of T2DM heritability in SSA are preference for maternal aggregation, higher among first degree compared to second-degree relatives; early age-onset (<50 years), and inherited abnormalities of beta-cell function/mass. The overall prevalence of T2DM was 28.2% for the population with a positive family history (PFH) and 11.2% for the population with negative family history (NFH). The pooled odds ratio of the impact of PFH on T2DM was 3.29 (95% CI: 2.40-4.52). Overall, 28 polymorphisms in 17 genes have been investigated in relation with T2DM in SSA. Almost all studies used the candidate gene approach with most (45.8%) of genetic studies published between 2011 and 2015. Polymorphisms in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.