Evidence map›Paper›PMID 32685535›Full record

ArticleBioMed research international2020

CircANXA2 Promotes Myocardial Apoptosis in Myocardial Ischemia-Reperfusion Injury via Inhibiting miRNA-133 Expression.

Liang Zong, Weixin Wang

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Landscape of Circular RNAs in Cardiovascular Diseases.International journal of molecular sciences · 2023
    Review
  8. Review
  9. LncRNA ROR modulates myocardial ischemia-reperfusion injury mediated by the miR-185-5p/CDK6 axis.Laboratory investigation; a journal of technical methods and pathology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
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  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Liang ZongDepartment of Cardiac Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Weixin WangDepartment of Cardiac Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.ORCID https://orcid.org/0000-0002-9824-6134

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis project is aimed at investigating whether CircANXA2 can promote the apoptosis of myocardial cells by inhibiting miR-133 expression and thereby participate in the development of myocardial ischemia-reperfusion injury.

resultqRT-PCR results showed that compared with the control, the expression of CircANXA2 was upregulated and the expression level of miR-133 was significantly decreased in H/R-treated H9c2 cells. CircANXA2 overexpression increased LDH, MDA, SOD, and GSH-PX activity in H/R-treated H9c2 cells. At the same time, CircANXA2 overexpression inhibited the proliferation of H/R-treated cells, and CircANXA2 was able to induce cardiomyocyte apoptosis. Western blot results showed that after overexpression of CircANXA2, the proapoptotic genes Bax and cytochrome C was upregulated, while the antiapoptotic gene Bcl-2 was downregulated. In H9c2 cells, upregulating miR-133 can reverse the inhibition of proliferation induced by CircANXA2 overexpression and increase apoptosis.

conclusionsCircANXA2 promotes cardiomyocyte apoptosis in myocardial ischemia-reperfusion injury by inhibiting the expression of miR-133. CircANXA2 may be a potential target for myocardial ischemia-reperfusion injury.

Indexed as

ApoptosisGene Expression RegulationAnimalsCell LineMicroRNAsMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacRatsRNA, CircularMicroRNAsMIRN133 microRNA, ratRNA, Circular

Identifiers

PMID32685535
PMCPMC7334784

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