ArticleInternational journal of surgical oncology2020
Predictive Factors of Positive Circumferential and Longitudinal Margins in Early T3 Colorectal Cancer Resection.
Article in International journal of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 14 citations in OpenAlex.
- A Vision Transformer- and Radiomics-based Model for Predicting Liver Metastasis-Free Survival in Patients with Rectal Cancer.Radiology. Imaging cancer · 2026Article
- The association of preoperative radiotherapy and surgery for AJCC stage I-III rectal adenocarcinoma: a population-based study.BMC surgery · 2024Article
- Outcomes of rectal cancer patients with a positive pathological circumferential resection margin.Langenbeck's archives of surgery · 2022Article
- Equivalent Operative Outcomes for Emergency Colon Cancer Resections Among Acute Care Surgeons and Specialists in Colorectal Surgery.The American surgeon · 2022Article
- MRI features of signet ring rectal cancer.Abdominal radiology (New York) · 2021Article
- Clinicopathological Factors Affecting Lymph Node Yield and Positivity in Left-Sided Colon and Rectal Cancers.Cureus · 2021Article
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3 authors at 2 institutions in 1 country.
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Abstract
backgroundMalignant involvement of circumferential resection margin (CRM) and longitudinal resection margin (LRM) after surgical resection of colorectal cancer (CRC) are associated with higher rates of recurrence and development of distant metastasis. This can influence the overall patient's prognosis. The aim of the current study was to identify pathological factors as predictors for the involvement of resection margins in early T3 CRC.
resultsPositive CRM was present in 17 cases (34%), while positive LRM was found in 6 cases (12%). The involvement of both margins was significantly associated with rectal tumors and tumors with infiltrative gross appearance, grade III, deeper invasion, and positive lymph node metastases. Also, there was a significant association between both margins' positivity and other pathological parameters as signet ring carcinoma, tumor budding, perineural and vascular invasion, high microvessel density (MVD), and sinusoidal vascular pattern, while the presence of necrosis and infiltrative advancing tumor front was significantly associated with CRM involvement only. The depth of tumor invasion and signet ring carcinoma were identified as independent predictor factors for positive CRM and LRM, respectively.
conclusionPreoperative identification of these pathological parameters can be a guide to tailor the management plan accordingly.
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